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    Novel and Emerging IngredientsNatural

    Spermidine

    Also known as: Spermidine trihydrochloride, Wheat-germ spermidine

    Triamine polyamine endogenously produced and dietary; induces autophagy via hypusination of eIF5A and other pathways.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    48/100
    AutophagyLongevityCardiovascular healthCognitive support
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Spermidine is a naturally occurring polyamine that induces autophagy, supporting cellular renewal, cardiovascular health, and cognitive performance in older adults.

    Mechanism & Function

    Mechanism of Action

    Triggers autophagy (cellular self-cleaning), supports cardiovascular function, and may attenuate cognitive decline.

    Physiological Role

    Used in longevity stacks; observational data link dietary spermidine to lower mortality; RCTs show cognitive benefits in mild cognitive impairment.

    Primary Pathways

    Autophagy induction (eIF5A hypusination)Cardiac protectionAnti-inflammatoryMitophagy

    Performance / Health Relevance

    Strong preclinical data; growing human evidence in cognition and cardiovascular endpoints.

    Evidence Review

    Overall48/100
    Human Clinical42/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic80/100
    Real-World48/100
    Safety85/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Practical Use & Dosage

    Minimum Effective Dose
    1 mg/day
    Optimal Range
    1–6 mg/day
    Upper / Caution Level
    ~10 mg/day
    Timing
    Morning, with or without food
    Best Format
    Capsule (wheat germ extract)
    Bioavailability
    Moderate; dietary intake well absorbed.
    Absorption Considerations
    Active intestinal polyamine transport.

    Safety & Interactions

    Side Effects

    • •Generally well tolerated

    Contraindications

    • Active cancer (variable theoretical effects)

    Drug Interactions

    • •NSAIDs (mild)

    Who Should Avoid

    • •Pregnancy (limited data)

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Spermidine typically used or indicated?

    Spermidine is most commonly used for: Autophagy, Longevity, Cardiovascular health, Cognitive support. Used in longevity stacks; observational data link dietary spermidine to lower mortality; RCTs show cognitive benefits in mild cognitive impairment.

    How does Spermidine work?

    Triggers autophagy (cellular self-cleaning), supports cardiovascular function, and may attenuate cognitive decline.

    What is the recommended dose of Spermidine?

    The optimal range is 1–6 mg/day. with a minimum effective dose of 1 mg/day. Best taken: Morning, with or without food. Upper / caution level: ~10 mg/day.

    What are the side effects of Spermidine?

    Reported side effects include: Generally well tolerated. Monitoring: None routine.

    Does Spermidine interact with medications?

    Known or theoretical interactions: NSAIDs (mild). Always check with a clinician before combining with prescription medication.

    Who should avoid Spermidine?

    Spermidine is generally not recommended for: Pregnancy (limited data); and Active cancer (variable theoretical effects).

    How strong is the evidence for Spermidine?

    Evidence level: Limited (overall score 48/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Spermidine on cognition in older adults with mild cognitive impairment

    RCT2018Moderate
    PubMed

    Significant improvement in memory performance vs placebo.

    Related Ingredients

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    62/100

    Trans-isomer of resveratrol; activates SIRT1, modulates AMPK, and provides antioxidant defence; rapidly metabolised to sulfate/glucuronide conjugates.

    NMN

    54/100

    Nicotinamide riboside monophosphate; converted to NAD+ via NMNAT enzymes; supports mitochondrial energy, DNA repair, and sirtuin-mediated longevity pathways.

    Urolithin A

    52/100

    A gut-derived dibenzopyranone metabolite of ellagitannins that activates mitophagy (selective autophagy of damaged mitochondria) via PINK1/Parkin and AMPK/ULK1 signaling pathways.

    Research Overview

    Limited Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2018Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceElderly
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/spermidine

    SuppIndex. (2026). Spermidine: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/spermidine

    Based on 1 indexed studies · Evidence level: Limited.

    Goal Ratings

    General Health
    Cognition
    Recovery

    Stack Compatibility

    Pair with NMN, resveratrol, fisetin for longevity stack.

    NMNTrans-ResveratrolFisetin