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    Novel and Emerging IngredientsNatural

    Trans-Resveratrol

    Also known as: Resveratrol, 3,5,4'-trihydroxy-trans-stilbene

    Trans-isomer of resveratrol; activates SIRT1, modulates AMPK, and provides antioxidant defence; rapidly metabolised to sulfate/glucuronide conjugates.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    62/100
    Sirtuin activatorCardiovascular healthLongevityAntioxidant
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Trans-resveratrol is a polyphenol from grapes and Japanese knotweed that activates SIRT1, supports cardiovascular function, and has shown longevity benefits in preclinical models.

    Mechanism & Function

    Mechanism of Action

    Activates SIRT1 (mimicking caloric restriction signalling), modulates lipid metabolism via AMPK, and supports endothelial function.

    Physiological Role

    Used in longevity and cardiovascular stacks; RCT evidence for endothelial function and modest glycaemic improvements in T2DM.

    Primary Pathways

    SIRT1 activationAMPK modulationEstrogen receptor modulationEndothelial NO support

    Performance / Health Relevance

    Mixed RCT evidence; consistent cardiovascular endpoint improvements; longevity outcomes long-term unknown.

    Evidence Review

    Overall62/100
    Human Clinical62/100
    Meta-Analysis58/100
    Mechanistic80/100
    Real-World58/100
    Safety86/100

    Practical Use & Dosage

    Minimum Effective Dose
    100 mg
    Optimal Range
    150–500 mg/day
    Upper / Caution Level
    ~1000 mg/day
    Timing
    With fat-containing meal
    Best Format
    Capsule (micronised or liposomal preferred)
    Bioavailability
    Very low — ~1% intact; metabolites circulate at higher levels.
    Absorption Considerations
    Micronised, phytosome, or liposomal forms substantially improve absorption.

    Safety & Interactions

    Side Effects

    • •Mild GI upset
    • •Diarrhoea at high doses

    Contraindications

    • Hormone-sensitive cancers (theoretical phytoestrogen)

    Drug Interactions

    • •CYP3A4 substrates
    • •Anticoagulants
    • •Antidiabetics

    Who Should Avoid

    • •Pregnancy

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Trans-Resveratrol typically used or indicated?

    Trans-Resveratrol is most commonly used for: Sirtuin activator, Cardiovascular health, Longevity, Antioxidant. Used in longevity and cardiovascular stacks; RCT evidence for endothelial function and modest glycaemic improvements in T2DM.

    How does Trans-Resveratrol work?

    Activates SIRT1 (mimicking caloric restriction signalling), modulates lipid metabolism via AMPK, and supports endothelial function.

    What is the recommended dose of Trans-Resveratrol?

    The optimal range is 150–500 mg/day. with a minimum effective dose of 100 mg. Best taken: With fat-containing meal. Upper / caution level: ~1000 mg/day.

    What are the side effects of Trans-Resveratrol?

    Reported side effects include: Mild GI upset; and Diarrhoea at high doses. Monitoring: None routine.

    Does Trans-Resveratrol interact with medications?

    Known or theoretical interactions: CYP3A4 substrates; Anticoagulants; and Antidiabetics. Always check with a clinician before combining with prescription medication.

    Who should avoid Trans-Resveratrol?

    Trans-Resveratrol is generally not recommended for: Pregnancy; and Hormone-sensitive cancers (theoretical phytoestrogen).

    How strong is the evidence for Trans-Resveratrol?

    Evidence level: Moderate (overall score 62/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Resveratrol for cardiovascular health: meta-analysis

    Meta-Analysis2015Moderate
    PubMed

    Significant improvement in flow-mediated dilation and modest lipid improvements.

    Trademark Ingredients

    ResverOx branded ingredient logo by VitaActives

    ResverOx

    Manufacturer: VitaActives

    Related Ingredients

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    Urolithin A

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    Nicotinamide Mononucleotide

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    A nucleotide intermediate in the NAD+ salvage pathway that is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT) enzymes, restoring cellular NAD+ pools critical for redox metabolism and epigenetic regulation.

    Research Overview

    Moderate Evidence
    1Total Studies
    0Human Trials
    1Meta-Analyses
    2015Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceMixed
    Pooled evidence (meta-analysis / systematic review)Yes

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/trans-resveratrol

    SuppIndex. (2026). Trans-Resveratrol: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/trans-resveratrol

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    General Health
    Recovery
    Metabolic Health

    Stack Compatibility

    Pair with NMN, pterostilbene, quercetin for longevity stack.

    NMNPterostilbeneQuercetin