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    Novel and Emerging IngredientsNatural

    Fisetin

    3,3',4',7-tetrahydroxyflavone; activates apoptosis selectively in senescent cells (senolysis), modulates SIRT1, and has direct antioxidant activity.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    42/100
    SenolyticLongevityCognitive supportAntioxidant
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Fisetin is a flavonoid found in strawberries and other plants that acts as a senolytic, selectively clearing senescent cells in preclinical models.

    Mechanism & Function

    Mechanism of Action

    Selectively clears senescent cells (zombie cells), reducing inflammatory burden; activates SIRT1 and provides neuroprotection.

    Physiological Role

    Used in longevity stacks; human RCTs ongoing; preclinical data show lifespan extension in mice.

    Primary Pathways

    Senolysis (senescent cell apoptosis)SIRT1 activationROS scavengingGlutathione enhancement

    Performance / Health Relevance

    Robust preclinical data; human trials limited; in active clinical investigation (Mayo Clinic).

    Evidence Review

    Overall42/100
    Human ClinicalN/A

    No human clinical studies indexed for this ingredient yet.

    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic85/100
    Real-World42/100
    Safety80/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Practical Use & Dosage

    Minimum Effective Dose
    100 mg/day
    Optimal Range
    100–500 mg/day (senolytic protocols use 20 mg/kg pulsed)
    Upper / Caution Level
    ~2000 mg/day pulsed
    Timing
    With fat (poor bioavailability)
    Best Format
    Capsule (liposomal preferred)
    Bioavailability
    Very poor — <1% oral; liposomal forms ~20× higher.
    Absorption Considerations
    Highly lipophilic; phytosome/liposomal formulations significantly improve absorption.

    Safety & Interactions

    Side Effects

    • •Mild GI upset

    Contraindications

    • Active cancer (timing-dependent)

    Drug Interactions

    • •CYP3A4 substrates
    • •Anticoagulants

    Who Should Avoid

    • •Pregnancy (limited data)

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Fisetin typically used or indicated?

    Fisetin is most commonly used for: Senolytic, Longevity, Cognitive support, Antioxidant. Used in longevity stacks; human RCTs ongoing; preclinical data show lifespan extension in mice.

    How does Fisetin work?

    Selectively clears senescent cells (zombie cells), reducing inflammatory burden; activates SIRT1 and provides neuroprotection.

    What is the recommended dose of Fisetin?

    The optimal range is 100–500 mg/day (senolytic protocols use 20 mg/kg pulsed). with a minimum effective dose of 100 mg/day. Best taken: With fat (poor bioavailability). Upper / caution level: ~2000 mg/day pulsed.

    What are the side effects of Fisetin?

    Reported side effects include: Mild GI upset. Monitoring: None routine.

    Does Fisetin interact with medications?

    Known or theoretical interactions: CYP3A4 substrates; and Anticoagulants. Always check with a clinician before combining with prescription medication.

    Who should avoid Fisetin?

    Fisetin is generally not recommended for: Pregnancy (limited data); and Active cancer (timing-dependent).

    How strong is the evidence for Fisetin?

    Evidence level: Limited (overall score 42/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Fisetin senolytic activity: preclinical lifespan extension

    Animal2018Moderate
    PubMed

    Fisetin extended median and maximum lifespan in mice; cleared senescent cells in multiple tissues.

    Related Ingredients

    Other top-rated ingredients in Novel and Emerging Ingredients.

    Trans-Resveratrol

    62/100

    Trans-isomer of resveratrol; activates SIRT1, modulates AMPK, and provides antioxidant defence; rapidly metabolised to sulfate/glucuronide conjugates.

    NMN

    54/100

    Nicotinamide riboside monophosphate; converted to NAD+ via NMNAT enzymes; supports mitochondrial energy, DNA repair, and sirtuin-mediated longevity pathways.

    Urolithin A

    52/100

    A gut-derived dibenzopyranone metabolite of ellagitannins that activates mitophagy (selective autophagy of damaged mitochondria) via PINK1/Parkin and AMPK/ULK1 signaling pathways.

    Research Overview

    Limited Evidence
    1Total Studies
    0Human Trials
    0Meta-Analyses
    2018Latest Study
    1Animal / In Vitro
    0Athlete Studies
    Primary data sourceAnimal
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/fisetin

    SuppIndex. (2026). Fisetin: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/fisetin

    Based on 1 indexed studies · Evidence level: Limited.

    Goal Ratings

    General Health
    Recovery
    Cognition

    Stack Compatibility

    Pulsed protocol with quercetin (common senolytic stack); pair with resveratrol.

    QuercetinTrans-ResveratrolSpermidine