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    NMN

    Also known as: Nicotinamide mononucleotide, β-NMN

    Nicotinamide riboside monophosphate; converted to NAD+ via NMNAT enzymes; supports mitochondrial energy, DNA repair, and sirtuin-mediated longevity pathways.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    54/100
    NAD+ precursorLongevityMetabolic healthCellular energy
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Nicotinamide mononucleotide (NMN) is a direct NAD+ precursor that raises systemic NAD+ levels, supporting cellular energy, sirtuin activity, and metabolic health.

    Mechanism & Function

    Mechanism of Action

    Raises tissue NAD+ levels that decline with age, supporting sirtuin function, mitochondrial biogenesis, and DNA repair.

    Physiological Role

    Used in longevity stacks; RCT evidence shows insulin sensitivity and aerobic capacity improvements in older adults; trained-athlete data emerging.

    Primary Pathways

    NAD+ biosynthesisSirtuin (SIRT1/3/6) activationMitochondrial biogenesisDNA repair (PARP-1)

    Performance / Health Relevance

    Human RCTs in middle-aged and older adults show NAD+ elevation and modest physiological benefits; long-term outcome data pending.

    Evidence Review

    Overall54/100
    Human Clinical58/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic85/100
    Real-World52/100
    Safety82/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Compare Vitamin B3 (Niacin) Forms

    5 vitamin b3 (niacin) forms are indexed. Bioavailability, clinical evidence, and best-use cases differ meaningfully between them.

    FormEvidence
    NMNThis page

    Oral NMN raises plasma NAD+; sublingual delivery may improve bypass of gut conversion.

    54/100
    Vitamin B3 (Niacin)

    Both nicotinic acid and nicotinamide are well absorbed orally. Nicotinic acid has varying pharmacokinetic profiles depending on the formulation (immediate-release vs. sustained-release).

    80/100
    Vitamin B3 (Niacinamide)

    Highly bioavailable orally, with absorption rates typically exceeding 90%.

    65/100
    Nicotinamide Riboside

    Oral NR increases circulating NAD+ and, in at least one trial, brain NAD+; magnitude of change is variable between individuals.

    61/100
    Nicotinamide Mononucleotide

    Rapidly absorbed and converted to NAD+ within 30 minutes. Some degradation by CD73 ectoenzyme in the GI tract — sublingual delivery may improve yield.

    50/100
    Open full side-by-side comparison

    Practical Use & Dosage

    Minimum Effective Dose
    125 mg/day
    Optimal Range
    250–500 mg/day
    Upper / Caution Level
    ~1000 mg/day
    Timing
    Morning, with or without food
    Best Format
    Capsule, sublingual
    Bioavailability
    Oral NMN raises plasma NAD+; sublingual delivery may improve bypass of gut conversion.
    Absorption Considerations
    Converted to nicotinamide riboside in gut, then to NMN intracellularly; mechanism debated.

    Safety & Interactions

    Side Effects

    • •Generally well tolerated

    Contraindications

    • Active cancer (theoretical NAD+ tumour support)

    Drug Interactions

    • •None established

    Who Should Avoid

    • •Pregnancy (limited data)

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is NMN typically used or indicated?

    NMN is most commonly used for: NAD+ precursor, Longevity, Metabolic health, Cellular energy. Used in longevity stacks; RCT evidence shows insulin sensitivity and aerobic capacity improvements in older adults; trained-athlete data emerging.

    How does NMN work?

    Raises tissue NAD+ levels that decline with age, supporting sirtuin function, mitochondrial biogenesis, and DNA repair.

    What is the recommended dose of NMN?

    The optimal range is 250–500 mg/day. with a minimum effective dose of 125 mg/day. Best taken: Morning, with or without food. Upper / caution level: ~1000 mg/day.

    What are the side effects of NMN?

    Reported side effects include: Generally well tolerated. Monitoring: None routine.

    Does NMN interact with medications?

    Known or theoretical interactions: None established. Always check with a clinician before combining with prescription medication.

    Who should avoid NMN?

    NMN is generally not recommended for: Pregnancy (limited data); and Active cancer (theoretical NAD+ tumour support).

    How strong is the evidence for NMN?

    Evidence level: Limited (overall score 54/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    NMN supplementation in middle-aged adults: RCT

    RCT2023Moderate
    PubMed

    Dose-dependent NAD+ elevation and improved 6-minute walk test.

    Related Ingredients

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    62/100

    Trans-isomer of resveratrol; activates SIRT1, modulates AMPK, and provides antioxidant defence; rapidly metabolised to sulfate/glucuronide conjugates.

    Urolithin A

    52/100

    A gut-derived dibenzopyranone metabolite of ellagitannins that activates mitophagy (selective autophagy of damaged mitochondria) via PINK1/Parkin and AMPK/ULK1 signaling pathways.

    Nicotinamide Mononucleotide

    50/100

    A nucleotide intermediate in the NAD+ salvage pathway that is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT) enzymes, restoring cellular NAD+ pools critical for redox metabolism and epigenetic regulation.

    Research Overview

    Limited Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2023Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceGeneral Population
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/nmn

    SuppIndex. (2026). NMN: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/nmn

    Based on 1 indexed studies · Evidence level: Limited.

    Goal Ratings

    General Health
    Recovery
    Metabolic Health
    Endurance

    Stack Compatibility

    Pair with TMG (methyl donor support), resveratrol (sirtuin synergy), pterostilbene.

    TMGTrans-ResveratrolPterostilbene

    Related evidence

    Compare NMN with other researched ingredients.

    Last reviewed Jun 2026