S7™
Also known as: Seven Plant-Based NO Booster, Plant-Derived Nitric Oxide Blend
A proprietary blend of seven plant extracts (green coffee bean, green tea, turmeric, tart cherry, blueberry, broccoli, kale) that upregulates endothelial nitric oxide synthase (eNOS) expression, increasing endogenous NO production by 230% at a 50mg dose.
Last reviewed: 2024-08-01 · 3 indexed studies
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Overview
S7™ is a clinically studied, low-dose (50mg) blend of seven plant-based ingredients that increases the body's own nitric oxide production by 230%. Unlike arginine or citrulline which provide NO precursors, S7™ works by upregulating endogenous eNOS enzyme activity — triggering the body to produce more NO from its own pathways.
Mechanism & Function
Brown low-dose plant extract blend (kale, blueberry, broccoli, turmeric, etc.).
- Capsule
- Powder
- Tablet
Capsule is generally preferred for bioavailability or efficacy.
Mechanism of Action
The polyphenol-rich plant complex activates eNOS gene expression and enzyme activity via Nrf2-mediated antioxidant signaling. By reducing oxidative quenching of NO (via superoxide dismutase upregulation) and simultaneously increasing eNOS activity, S7™ amplifies net bioavailable NO without providing exogenous arginine substrate. The mechanism is fundamentally different from and complementary to citrulline/arginine-based NO strategies.
Physiological Role
Provides concentrated plant polyphenols that modulate endothelial function through antioxidant and eNOS-activating pathways. Supports vascular health at the gene expression level rather than through substrate provision.
Primary Pathways
Performance / Health Relevance
Increases systemic NO by 230% at just 50mg — making it an extremely dose-efficient pump ingredient. Complementary to citrulline (substrate) and Nitrosigine (sustained arginine). Ideal for clean-label and plant-based formulations where synthetic NO precursors are undesired.
Evidence Review
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- 25mg/day
- Optimal Range
- 50mg/day (clinically validated dose)
- Upper / Caution Level
- 150mg/day
- Timing
- Pre-workout (30 min prior); effects are relatively rapid
- Best Format
- Powder blend in pre-workout or capsule
- Bioavailability
- Low dose (50mg) makes it easy to formulate. Plant polyphenol matrix may have synergistic absorption properties. Active at a fraction of the dose required for citrulline or arginine.
- Absorption Considerations
- Can be taken with or without food. The small dose minimizes any GI concerns. Polyphenol bioavailability is enhanced by the multi-plant matrix.
Safety & Interactions
Side Effects
- •No adverse events reported in clinical studies
- •Minimal caffeine content from green coffee bean and green tea (negligible at 50mg dose)
Contraindications
- Known allergy to any of the seven plant ingredients (green coffee bean, green tea, turmeric, tart cherry, blueberry, broccoli, kale)
Drug Interactions
- •PDE5 inhibitors (theoretical — additive NO)
- •Antihypertensives (monitor blood pressure)
Who Should Avoid
- •Those with allergies to any of the seven plant ingredients
Monitoring
Extremely well tolerated at clinical dose. No significant monitoring needed for healthy adults.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is S7™ typically used or indicated?
S7™ is most commonly used for: Endogenous NO production, Plant-based pump, Low-dose vasodilation, Clean-label formulation. Provides concentrated plant polyphenols that modulate endothelial function through antioxidant and eNOS-activating pathways. Supports vascular health at the gene expression level rather than through substrate provision.
How does S7™ work?
The polyphenol-rich plant complex activates eNOS gene expression and enzyme activity via Nrf2-mediated antioxidant signaling. By reducing oxidative quenching of NO (via superoxide dismutase upregulation) and simultaneously increasing eNOS activity, S7™ amplifies net bioavailable NO without providing exogenous arginine substrate. The mechanism is fundamentally different from and complementary to citrulline/arginine-based NO strategies.
What is the recommended dose of S7™?
The optimal range is 50mg/day (clinically validated dose). with a minimum effective dose of 25mg/day. Best taken: Pre-workout (30 min prior); effects are relatively rapid. Upper / caution level: 150mg/day.
What are the side effects of S7™?
Reported side effects include: No adverse events reported in clinical studies; and Minimal caffeine content from green coffee bean and green tea (negligible at 50mg dose). Monitoring: Extremely well tolerated at clinical dose. No significant monitoring needed for healthy adults.
Does S7™ interact with medications?
Known or theoretical interactions: PDE5 inhibitors (theoretical — additive NO); and Antihypertensives (monitor blood pressure). Always check with a clinician before combining with prescription medication.
Who should avoid S7™?
S7™ is generally not recommended for: Those with allergies to any of the seven plant ingredients; and Known allergy to any of the seven plant ingredients (green coffee bean, green tea, turmeric, tart cherry, blueberry, broccoli, kale).
How strong is the evidence for S7™?
Evidence level: Moderate (overall score 64/100), based on 3 indexed studies on SuppIndex.
Research & References (3)
A blend of seven plant extracts increases endogenous nitric oxide production
Double-blind, placebo-controlled crossover study demonstrating 50mg S7™ increased salivary and plasma NOx (nitric oxide metabolites) by 230% compared to placebo within 3 hours of ingestion.
Effect of a seven-plant polyphenol blend on flow-mediated dilation in healthy adults
Follow-up RCT examining endothelial function via flow-mediated dilation (FMD) after S7 supplementation.
Polyphenol-induced eNOS upregulation: mechanistic in vitro evidence
Mechanistic study of plant polyphenols on endothelial nitric oxide synthase expression.
Trademark Ingredients
Related Ingredients
Other top-rated ingredients in Pump and Performance Ingredients.
Nitrosigine®
82/100Inositol-stabilized arginine silicate complex that provides sustained elevation of plasma arginine (up to 6 hours) and silicon, enhancing eNOS-mediated nitric oxide production, vascular compliance, and cognitive flexibility during physical exertion.
Beetroot Extract
80/100Concentrated source of dietary inorganic nitrate that undergoes serial reduction via oral microbiome (NO₃⁻ → NO₂⁻) and tissue-level reduction (NO₂⁻ → NO) through the oxygen-independent nitrate-nitrite-NO pathway, enhancing blood flow and exercise efficiency.
Citrulline Malate
78/100Salt of L-citrulline and DL-malic acid (commonly 2:1); citrulline raises plasma arginine and NO; malate enters the Krebs cycle and may buffer fatigue.
Research Overview
Moderate EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/s7
SuppIndex. (2026). S7: Evidence summary, dosage and clinical studies. Retrieved October 23, 2026, from https://thesuppindex.com/ingredients/s7
Based on 3 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
Designed to stack with citrulline and Nitrosigine for triple-pathway NO enhancement: S7 (eNOS upregulation) + citrulline (arginine recycling) + Nitrosigine (sustained arginine delivery). The gold standard pump trifecta.
Products (3)
Ghost
Ghost Legend V3
Kaged
Pre-Kaged Elite
3D Labs Nutrition
Pump 365