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    Botanical ExtractsNatural

    Zynamite Mangifera Indica

    Also known as: Mango leaf extract, Mangiferin, Zynamite

    Standardised Mangifera indica leaf extract delivering mangiferin and related polyphenols; modulates adenosine signalling and provides antioxidant effects.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    62/100
    Cognitive performanceEnduranceRecoveryNon-stimulant focus
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Zynamite is a standardised mango leaf extract (≥60% mangiferin) that has shown ergogenic and cognitive benefits without stimulant side effects.

    Mechanism & Function

    Mechanism of Action

    Improves brain activation (EEG), reaction time, and exercise performance without stimulating heart rate or blood pressure.

    Physiological Role

    RCTs in cyclists show improved peak power and time-trial performance with 140 mg dose; cognitive RCTs show reaction time and attention benefits.

    Primary Pathways

    Adenosine modulationPolyphenol antioxidantMitochondrial supportNitric oxide modulation

    Performance / Health Relevance

    Multiple RCTs in athletes and cognitively-demanding tasks; manufacturer-supported but independently replicated.

    Evidence Review

    Overall62/100
    Human Clinical68/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic75/100
    Real-World62/100
    Safety88/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Practical Use & Dosage

    Minimum Effective Dose
    140 mg
    Optimal Range
    140–300 mg per dose
    Upper / Caution Level
    ~420 mg/day
    Timing
    60 min pre-exercise/task
    Best Format
    Capsule, powder
    Bioavailability
    Moderate — improved with co-ingestion of fat.
    Absorption Considerations
    Mangiferin enterohepatically circulated; effects sustained 2–4 h.

    Safety & Interactions

    Side Effects

    • •Generally well tolerated

    Contraindications

    • Mango allergy

    Drug Interactions

    • •Anticoagulants (theoretical)

    Who Should Avoid

    • •Mango allergy

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Zynamite Mangifera Indica typically used or indicated?

    Zynamite Mangifera Indica is most commonly used for: Cognitive performance, Endurance, Recovery, Non-stimulant focus. RCTs in cyclists show improved peak power and time-trial performance with 140 mg dose; cognitive RCTs show reaction time and attention benefits.

    How does Zynamite Mangifera Indica work?

    Improves brain activation (EEG), reaction time, and exercise performance without stimulating heart rate or blood pressure.

    What is the recommended dose of Zynamite Mangifera Indica?

    The optimal range is 140–300 mg per dose. with a minimum effective dose of 140 mg. Best taken: 60 min pre-exercise/task. Upper / caution level: ~420 mg/day.

    What are the side effects of Zynamite Mangifera Indica?

    Reported side effects include: Generally well tolerated. Monitoring: None routine.

    Does Zynamite Mangifera Indica interact with medications?

    Known or theoretical interactions: Anticoagulants (theoretical). Always check with a clinician before combining with prescription medication.

    Who should avoid Zynamite Mangifera Indica?

    Zynamite Mangifera Indica is generally not recommended for: Mango allergy; and Mango allergy.

    How strong is the evidence for Zynamite Mangifera Indica?

    Evidence level: Moderate (overall score 62/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Zynamite mango leaf extract on exercise performance

    RCT2019Moderate
    PubMed

    Significant improvement in peak power output and TTE.

    Trademark Ingredients

    Zynamite®

    Manufacturer:

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    Research Overview

    Moderate Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2019Latest Study
    0Animal / In Vitro
    1Athlete Studies
    Primary data sourceAthletes
    Pooled evidence (meta-analysis / systematic review)No
    Athlete-specific data1 studies

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/zynamite-mangifera-indica

    SuppIndex. (2026). Zynamite Mangifera Indica: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/zynamite-mangifera-indica

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    Endurance
    Focus
    Cognition
    Recovery

    Stack Compatibility

    Pair with caffeine (synergistic), or use as non-stim alternative.

    Caffeine AnhydrousQuercetinL-Theanine