CoQ10
Also known as: Coenzyme Q10, Ubiquinone, Ubiquinol
Endogenous lipid-soluble ubiquinone/ubiquinol that shuttles electrons in the mitochondrial respiratory chain and acts as a membrane antioxidant.
Last reviewed: 2026-06-23 · 1 indexed study
Set your location for accurate regulatory status
Saved on this device — no sign-in needed.
Overview
Coenzyme Q10 (ubiquinone) is a mitochondrial electron carrier and lipophilic antioxidant; supplementation supports energy production, heart health, and counters statin-induced depletion.
Mechanism & Function
Mechanism of Action
Supports oxidative phosphorylation, ATP production, and membrane antioxidant defence; declines with age and statin use.
Physiological Role
Multiple RCTs in heart failure, statin myalgia, migraine prevention, and fertility; ergogenic effects in athletes are modest.
Primary Pathways
Performance / Health Relevance
Robust evidence in heart failure (Q-SYMBIO trial), statin myalgia, and migraine; mitochondrial support broadly.
Evidence Review
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- 100 mg/day
- Optimal Range
- 100–200 mg/day (ubiquinol preferred for older adults)
- Upper / Caution Level
- ~600 mg/day in clinical use
- Timing
- With fat-containing meal
- Best Format
- Softgel (oil-based) or solubilised
- Bioavailability
- Highly lipophilic — fat co-ingestion essential; ubiquinol ~2–3× more bioavailable than ubiquinone.
- Absorption Considerations
- Lymphatic absorption; Tmax ~6 h.
Safety & Interactions
Side Effects
- •Mild GI upset
- •Insomnia if taken late
- •Rare rash
Contraindications
- None established
Drug Interactions
- •Warfarin (mild interaction)
- •Statins (CoQ10 depletes)
- •Antihypertensives
Who Should Avoid
- •Pregnancy at high doses
Monitoring
INR if on warfarin.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is CoQ10 typically used or indicated?
CoQ10 is most commonly used for: Mitochondrial function, Cardiovascular health, Energy, Statin support, Fertility. Multiple RCTs in heart failure, statin myalgia, migraine prevention, and fertility; ergogenic effects in athletes are modest.
How does CoQ10 work?
Supports oxidative phosphorylation, ATP production, and membrane antioxidant defence; declines with age and statin use.
What is the recommended dose of CoQ10?
The optimal range is 100–200 mg/day (ubiquinol preferred for older adults). with a minimum effective dose of 100 mg/day. Best taken: With fat-containing meal. Upper / caution level: ~600 mg/day in clinical use.
What are the side effects of CoQ10?
Reported side effects include: Mild GI upset; Insomnia if taken late; and Rare rash. Monitoring: INR if on warfarin.
Does CoQ10 interact with medications?
Known or theoretical interactions: Warfarin (mild interaction); Statins (CoQ10 depletes); and Antihypertensives. Always check with a clinician before combining with prescription medication.
Who should avoid CoQ10?
CoQ10 is generally not recommended for: Pregnancy at high doses; and None established.
How strong is the evidence for CoQ10?
Evidence level: Strong (overall score 78/100), based on 1 indexed study on SuppIndex.
Research & References (1)
CoQ10 in heart failure: Q-SYMBIO trial
42% reduction in MACE vs placebo in chronic heart failure.
Trademark Ingredients
Related Ingredients
Other top-rated ingredients in General Health Ingredients.
Piperine
82/100A piperidine alkaloid (C₁₇H₁₉NO₃) that inhibits cytochrome P450 enzymes (CYP3A4, CYP1A2, CYP2E1), P-glycoprotein efflux transporters, and UDP-glucuronosyltransferases while enhancing intestinal permeability, digestive enzyme secretion, and splanchnic blood flow — collectively producing dramatic improvements in nutrient bioavailability.
Beta-Glucan (Oat)
77/100Multiple randomized trials and meta-analyses report that ≥3 g/day oat beta-glucan lowers LDL and total cholesterol modestly. Acute feeding trials pooled in meta-analysis show dose- and molecular-weight–dependent reductions in postprandial glucose and insulin responses.
Cinnamon
75/100Randomized trials and meta-analyses report that cinnamon supplementation can lower fasting glucose, HbA1c and some insulin-resistance measures in people with type 2 diabetes and can reduce measures of body weight and waist circumference in some trials. Individual trial results vary and heterogeneity between studies is noted.
Research Overview
Strong EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/coq10
SuppIndex. (2026). CoQ10: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/coq10
Based on 1 indexed studies · Evidence level: Strong.
Goal Ratings
Stack Compatibility
Pair with omega-3, magnesium; essential adjunct for statin users.