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    Infinergy Dicaffeine Malate

    Also known as: Dicaffeine malate, Infinergy, Caffeine malate

    Caffeine + malic acid ionic complex; releases caffeine at near-identical rate to anhydrous in pharmacokinetic studies, with malate entering the TCA cycle.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    60/100
    Sustained energyReduced caffeine crashSmoother stimulation
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Infinergy is caffeine ionically bonded to malic acid (~75% caffeine by mass), marketed for slightly slower absorption, reduced GI upset, and a smoother energy curve than caffeine anhydrous.

    Mechanism & Function

    Mechanism of Action

    Same mechanism as caffeine (adenosine antagonism) with potential modest GI tolerance benefit; pharmacokinetic differences are small.

    Physiological Role

    Used in pre-workouts to blend with anhydrous caffeine for theoretically smoother stimulation; ergogenic effects equivalent to dose-matched caffeine anhydrous.

    Primary Pathways

    Adenosine A1/A2A antagonismCatecholamine releaseMalate→TCA cycle

    Performance / Health Relevance

    Manufacturer-funded data and product positioning; head-to-head clinical data show near-equivalent pharmacokinetics to anhydrous caffeine.

    Evidence Review

    Overall60/100
    Human Clinical62/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic78/100
    Real-World62/100
    Safety85/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Practical Use & Dosage

    Minimum Effective Dose
    100 mg (≈75 mg caffeine)
    Optimal Range
    200–400 mg Infinergy per pre-workout
    Upper / Caution Level
    ~600 mg (~450 mg caffeine)
    Timing
    30 min pre-exercise
    Best Format
    Powder, capsule
    Bioavailability
    ~99% caffeine bioavailability after ionic dissociation.
    Absorption Considerations
    Slightly slower absorption than anhydrous in some PK studies; similar Cmax.

    Safety & Interactions

    Side Effects

    • •Same as caffeine — jitters, tachycardia, insomnia

    Contraindications

    • Same as caffeine

    Drug Interactions

    • •Same as caffeine

    Who Should Avoid

    • •Same as caffeine

    Monitoring

    None beyond caffeine considerations.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Infinergy Dicaffeine Malate typically used or indicated?

    Infinergy Dicaffeine Malate is most commonly used for: Sustained energy, Reduced caffeine crash, Smoother stimulation. Used in pre-workouts to blend with anhydrous caffeine for theoretically smoother stimulation; ergogenic effects equivalent to dose-matched caffeine anhydrous.

    How does Infinergy Dicaffeine Malate work?

    Same mechanism as caffeine (adenosine antagonism) with potential modest GI tolerance benefit; pharmacokinetic differences are small.

    What is the recommended dose of Infinergy Dicaffeine Malate?

    The optimal range is 200–400 mg Infinergy per pre-workout. with a minimum effective dose of 100 mg (≈75 mg caffeine). Best taken: 30 min pre-exercise. Upper / caution level: ~600 mg (~450 mg caffeine).

    What are the side effects of Infinergy Dicaffeine Malate?

    Reported side effects include: Same as caffeine — jitters, tachycardia, insomnia. Monitoring: None beyond caffeine considerations.

    Does Infinergy Dicaffeine Malate interact with medications?

    Known or theoretical interactions: Same as caffeine. Always check with a clinician before combining with prescription medication.

    Who should avoid Infinergy Dicaffeine Malate?

    Infinergy Dicaffeine Malate is generally not recommended for: Same as caffeine; and Same as caffeine.

    How strong is the evidence for Infinergy Dicaffeine Malate?

    Evidence level: Moderate (overall score 60/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Pharmacokinetics of caffeine anhydrous vs dicaffeine malate

    RCT2019Low

    Similar Cmax; Infinergy showed marginally extended Tmax.

    Trademark Ingredients

    Infinergy®

    Manufacturer:

    Related Ingredients

    Other top-rated ingredients in Nootropics.

    Caffeine Anhydrous

    90/100

    Methylxanthine alkaloid; non-selective adenosine A1/A2A receptor antagonist; raises cAMP, catecholamine release, and Ca²⁺ sensitivity in muscle.

    Alpha-GPC

    78/100

    Highly bioavailable choline donor that elevates brain acetylcholine levels, supporting memory, learning, and muscular power output via enhanced neuromuscular junction signaling.

    L-Theanine

    72/100

    A non-proteinogenic amino acid analog of glutamate that crosses the BBB, promoting alpha-wave brain activity and modulating inhibitory neurotransmitter balance.

    Research Overview

    Moderate Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2019Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceGeneral Population
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/infinergy-dicaffeine-malate

    SuppIndex. (2026). Infinergy Dicaffeine Malate: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/infinergy-dicaffeine-malate

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    Focus
    Endurance
    Strength
    Fat Loss

    Stack Compatibility

    Common in blended pre-workouts with anhydrous caffeine for sustained release.

    Caffeine AnhydrousL-TheanineBeta-Alanine