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    Botanical ExtractsNatural

    Grapeseed Extract

    Also known as: Vitis vinifera seed extract, GSE, OPCs

    Standardised Vitis vinifera seed extract (typically ≥95% OPCs); modulates eNOS, scavenges free radicals, and supports collagen cross-linking.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    62/100
    Vascular healthAntioxidantBlood pressure support
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Grapeseed extract is rich in oligomeric proanthocyanidins (OPCs) supporting vascular health, antioxidant defence, and modest blood pressure reduction.

    Mechanism & Function

    Mechanism of Action

    Supports endothelial NO production, scavenges ROS, and inhibits xanthine oxidase, reducing oxidative damage.

    Physiological Role

    Useful as general vascular adjunct; can pair with cardiovascular stacks. Modest ergogenic value alone.

    Primary Pathways

    eNOS activationOPC antioxidantCollagen supportACE modulation

    Performance / Health Relevance

    Meta-analyses show modest BP reduction; vascular health benefits established.

    Evidence Review

    Overall62/100
    Human Clinical68/100
    Meta-Analysis65/100
    Mechanistic78/100
    Real-World58/100
    Safety90/100

    Practical Use & Dosage

    Minimum Effective Dose
    100 mg
    Optimal Range
    150–300 mg/day
    Upper / Caution Level
    ~600 mg/day
    Timing
    With meals
    Best Format
    Capsule
    Bioavailability
    OPCs partially absorbed intact; gut metabolites contribute.
    Absorption Considerations
    Small intestine absorption with gut microbiota involvement.

    Safety & Interactions

    Side Effects

    • •Mild GI upset

    Contraindications

    • Pregnancy (high doses)

    Drug Interactions

    • •Anticoagulants
    • •Antihypertensives

    Who Should Avoid

    • •Surgery within 2 weeks

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Grapeseed Extract typically used or indicated?

    Grapeseed Extract is most commonly used for: Vascular health, Antioxidant, Blood pressure support. Useful as general vascular adjunct; can pair with cardiovascular stacks. Modest ergogenic value alone.

    How does Grapeseed Extract work?

    Supports endothelial NO production, scavenges ROS, and inhibits xanthine oxidase, reducing oxidative damage.

    What is the recommended dose of Grapeseed Extract?

    The optimal range is 150–300 mg/day. with a minimum effective dose of 100 mg. Best taken: With meals. Upper / caution level: ~600 mg/day.

    What are the side effects of Grapeseed Extract?

    Reported side effects include: Mild GI upset. Monitoring: None routine.

    Does Grapeseed Extract interact with medications?

    Known or theoretical interactions: Anticoagulants; and Antihypertensives. Always check with a clinician before combining with prescription medication.

    Who should avoid Grapeseed Extract?

    Grapeseed Extract is generally not recommended for: Surgery within 2 weeks; and Pregnancy (high doses).

    How strong is the evidence for Grapeseed Extract?

    Evidence level: Moderate (overall score 62/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Grape seed extract on blood pressure: meta-analysis

    Meta-Analysis2016Moderate
    PubMed

    Significant SBP reduction (~6 mmHg) in obese and metabolic-syndrome populations.

    Trademark Ingredients

    Envitis branded ingredient logo by VitaActives

    Envitis

    Manufacturer: VitaActives

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    Research Overview

    Moderate Evidence
    1Total Studies
    0Human Trials
    1Meta-Analyses
    2016Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceMixed
    Pooled evidence (meta-analysis / systematic review)Yes

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/grapeseed-extract

    SuppIndex. (2026). Grapeseed Extract: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/grapeseed-extract

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    General Health
    Recovery
    Endurance

    Stack Compatibility

    Pair with vitamin C, pine bark, CoQ10.

    Vitamin CPine Bark ExtractCoQ10