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    Botanical ExtractsNatural

    CognatiQ CoffeeBerry

    Also known as: Whole coffee fruit extract, CognatiQ, Coffee cherry

    Standardised Coffea arabica fruit extract; rich in chlorogenic acids and polyphenols; raises serum BDNF acutely.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    60/100
    BDNF supportCognitive performanceMoodMemory
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    CognatiQ is a patented whole coffee fruit (coffeeberry) extract clinically shown to elevate plasma BDNF, supporting cognitive performance and mood.

    Mechanism & Function

    Mechanism of Action

    Acutely elevates BDNF (~140% increase in trials), supporting synaptic plasticity, memory consolidation, and mood.

    Physiological Role

    Useful in cognitive performance stacks and pre-workouts; modest stimulant content (~20 mg caffeine per dose).

    Primary Pathways

    BDNF upregulationSynaptic plasticityPolyphenol antioxidant

    Performance / Health Relevance

    Manufacturer-funded RCTs show acute BDNF elevation; behavioural/cognitive endpoint data is growing.

    Evidence Review

    Overall60/100
    Human Clinical62/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic75/100
    Real-World58/100
    Safety86/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Practical Use & Dosage

    Minimum Effective Dose
    100 mg
    Optimal Range
    100–300 mg/day
    Upper / Caution Level
    ~600 mg/day
    Timing
    Morning or pre-task
    Best Format
    Capsule, powder
    Bioavailability
    Moderate — chlorogenic acids absorbed in small intestine and colon.
    Absorption Considerations
    Plasma BDNF rise within 1–2 h post-dose.

    Safety & Interactions

    Side Effects

    • •Mild GI upset
    • •Minor caffeine-related effects

    Contraindications

    • Severe caffeine sensitivity

    Drug Interactions

    • •Stimulants

    Who Should Avoid

    • •Pregnancy >300 mg

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is CognatiQ CoffeeBerry typically used or indicated?

    CognatiQ CoffeeBerry is most commonly used for: BDNF support, Cognitive performance, Mood, Memory. Useful in cognitive performance stacks and pre-workouts; modest stimulant content (~20 mg caffeine per dose).

    How does CognatiQ CoffeeBerry work?

    Acutely elevates BDNF (~140% increase in trials), supporting synaptic plasticity, memory consolidation, and mood.

    What is the recommended dose of CognatiQ CoffeeBerry?

    The optimal range is 100–300 mg/day. with a minimum effective dose of 100 mg. Best taken: Morning or pre-task. Upper / caution level: ~600 mg/day.

    What are the side effects of CognatiQ CoffeeBerry?

    Reported side effects include: Mild GI upset; and Minor caffeine-related effects. Monitoring: None routine.

    Does CognatiQ CoffeeBerry interact with medications?

    Known or theoretical interactions: Stimulants. Always check with a clinician before combining with prescription medication.

    Who should avoid CognatiQ CoffeeBerry?

    CognatiQ CoffeeBerry is generally not recommended for: Pregnancy >300 mg; and Severe caffeine sensitivity.

    How strong is the evidence for CognatiQ CoffeeBerry?

    Evidence level: Moderate (overall score 60/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Whole coffee fruit extract increases plasma BDNF

    RCT2013Moderate
    PubMed

    Significant acute BDNF elevation vs placebo, with sustained effect over 4 weeks daily use.

    Trademark Ingredients

    CognatiQ®

    Manufacturer:

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    Research Overview

    Moderate Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2013Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceGeneral Population
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/cognatiq-coffeeberry

    SuppIndex. (2026). CognatiQ CoffeeBerry: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/cognatiq-coffeeberry

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    Cognition
    Focus
    Recovery

    Stack Compatibility

    Synergistic with Lion's Mane, Bacopa, Alpha-GPC for memory stack.

    Lion's ManeBacopa MonnieriAlpha-GPC