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    Botanical ExtractsNatural

    Citrus Bergamot

    Also known as: Citrus bergamia, Bergamot polyphenols, BPF

    Standardised Citrus bergamia juice extract delivering bergamot polyphenolic fraction (BPF) including brutieridin, melitidin, and naringin.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    74/100
    Lipid managementCardiovascular healthGlycaemic supportLiver health
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Citrus bergamot polyphenolic extract (BPF) lowers LDL cholesterol, raises HDL, and supports glycaemic and hepatic health through flavonoid-mediated HMG-CoA reductase inhibition.

    Mechanism & Function

    Mechanism of Action

    Brutieridin and melitidin (statin-like flavonoids) inhibit HMG-CoA reductase, lowering LDL synthesis; activates AMPK, improving insulin signalling and lipid oxidation.

    Physiological Role

    Strong RCT evidence for lipid lowering; emerging evidence for NAFLD and glycaemic outcomes; useful adjunct to or alternative for mild hypercholesterolaemia.

    Primary Pathways

    HMG-CoA reductase inhibitionAMPK activationPCSK9 modulationROS scavenging

    Performance / Health Relevance

    Multiple RCTs show 25–30% LDL reductions; comparable to low-dose statins in mild dyslipidaemia.

    Evidence Review

    Overall74/100
    Human Clinical80/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic82/100
    Real-World72/100
    Safety92/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Practical Use & Dosage

    Minimum Effective Dose
    500 mg
    Optimal Range
    500–1000 mg/day BPF
    Upper / Caution Level
    ~1500 mg/day
    Timing
    With meals
    Best Format
    Capsule
    Bioavailability
    Moderate.
    Absorption Considerations
    Polyphenols absorbed in small intestine and colon.

    Safety & Interactions

    Side Effects

    • •Mild GI upset
    • •Heartburn

    Contraindications

    • Pregnancy
    • Statin-related rhabdomyolysis history

    Drug Interactions

    • •Statins (additive)
    • •CYP3A4 substrates
    • •Anticoagulants

    Who Should Avoid

    • •Citrus allergy

    Monitoring

    Lipid panel periodically.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Citrus Bergamot typically used or indicated?

    Citrus Bergamot is most commonly used for: Lipid management, Cardiovascular health, Glycaemic support, Liver health. Strong RCT evidence for lipid lowering; emerging evidence for NAFLD and glycaemic outcomes; useful adjunct to or alternative for mild hypercholesterolaemia.

    How does Citrus Bergamot work?

    Brutieridin and melitidin (statin-like flavonoids) inhibit HMG-CoA reductase, lowering LDL synthesis; activates AMPK, improving insulin signalling and lipid oxidation.

    What is the recommended dose of Citrus Bergamot?

    The optimal range is 500–1000 mg/day BPF. with a minimum effective dose of 500 mg. Best taken: With meals. Upper / caution level: ~1500 mg/day.

    What are the side effects of Citrus Bergamot?

    Reported side effects include: Mild GI upset; and Heartburn. Monitoring: Lipid panel periodically.

    Does Citrus Bergamot interact with medications?

    Known or theoretical interactions: Statins (additive); CYP3A4 substrates; and Anticoagulants. Always check with a clinician before combining with prescription medication.

    Who should avoid Citrus Bergamot?

    Citrus Bergamot is generally not recommended for: Citrus allergy; Pregnancy; and Statin-related rhabdomyolysis history.

    How strong is the evidence for Citrus Bergamot?

    Evidence level: Moderate (overall score 74/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Bergamot polyphenolic fraction on lipid and glycaemic profile

    RCT2013Strong
    PubMed

    Dose-dependent LDL reduction (25–30%) and improved glycaemic markers.

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    Research Overview

    Moderate Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2013Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceClinical Patients
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/citrus-bergamot

    SuppIndex. (2026). Citrus Bergamot: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/citrus-bergamot

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    Metabolic Health
    General Health

    Stack Compatibility

    Pair with omega-3, berberine, plant sterols for lipid stack.

    Omega-3 (EPA/DHA)BerberinePlant Sterols