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    Botanical ExtractsNatural

    CellFlo6

    Also known as: Cocoa flavanol extract, CellFlo6

    Cocoa-derived flavanol blend (epicatechin-rich) that acutely activates endothelial nitric oxide synthase (eNOS) and increases bioavailable NO.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    58/100
    PumpeNOS activationVascular function
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    CellFlo6 is a standardised cocoa flavanol-rich extract patented for its acute eNOS-activating, vasodilatory effects supporting pump and vascular function.

    Mechanism & Function

    Mechanism of Action

    Stimulates eNOS phosphorylation, raises endothelial NO, dilates blood vessels, and supports cerebral and muscular blood flow.

    Physiological Role

    Used in pre-workouts for non-stimulant pump; cocoa flavanols show vascular benefits in cardiovascular RCTs.

    Primary Pathways

    eNOS activationNO bioavailabilityEndothelial function

    Performance / Health Relevance

    Manufacturer-supported acute pharmacology; broader cocoa flavanol literature supports vascular endpoints.

    Evidence Review

    Overall58/100
    Human Clinical58/100
    Meta-Analysis48/100
    Mechanistic78/100
    Real-World58/100
    Safety90/100

    Practical Use & Dosage

    Minimum Effective Dose
    100 mg
    Optimal Range
    200–400 mg pre-exercise
    Upper / Caution Level
    ~600 mg/day
    Timing
    30–60 min pre-exercise
    Best Format
    Powder, capsule
    Bioavailability
    Epicatechin Cmax ~2 h; sustained eNOS effects ~3 h.
    Absorption Considerations
    Small-intestine absorption with phase II metabolism.

    Safety & Interactions

    Side Effects

    • •Generally well tolerated

    Contraindications

    • Stimulant sensitivity (trace caffeine)

    Drug Interactions

    • •Antihypertensives

    Who Should Avoid

    • •Cocoa allergy (rare)

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is CellFlo6 typically used or indicated?

    CellFlo6 is most commonly used for: Pump, eNOS activation, Vascular function. Used in pre-workouts for non-stimulant pump; cocoa flavanols show vascular benefits in cardiovascular RCTs.

    How does CellFlo6 work?

    Stimulates eNOS phosphorylation, raises endothelial NO, dilates blood vessels, and supports cerebral and muscular blood flow.

    What is the recommended dose of CellFlo6?

    The optimal range is 200–400 mg pre-exercise. with a minimum effective dose of 100 mg. Best taken: 30–60 min pre-exercise. Upper / caution level: ~600 mg/day.

    What are the side effects of CellFlo6?

    Reported side effects include: Generally well tolerated. Monitoring: None routine.

    Does CellFlo6 interact with medications?

    Known or theoretical interactions: Antihypertensives. Always check with a clinician before combining with prescription medication.

    Who should avoid CellFlo6?

    CellFlo6 is generally not recommended for: Cocoa allergy (rare); and Stimulant sensitivity (trace caffeine).

    How strong is the evidence for CellFlo6?

    Evidence level: Moderate (overall score 58/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Cocoa flavanols on endothelial function: meta-analysis

    Meta-Analysis2017Strong
    PubMed

    Significant acute and chronic improvement in FMD.

    Trademark Ingredients

    CellFlo6®

    Manufacturer:

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    Research Overview

    Moderate Evidence
    1Total Studies
    0Human Trials
    1Meta-Analyses
    2017Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceMixed
    Pooled evidence (meta-analysis / systematic review)Yes

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/cellflo6

    SuppIndex. (2026). CellFlo6: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/cellflo6

    Based on 1 indexed studies · Evidence level: Moderate.

    Goal Ratings

    Endurance
    Recovery
    Cognition

    Stack Compatibility

    Synergistic with L-citrulline and beetroot for pump.

    L-CitrullineBeetrootPycnogenol