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    Calcium AKG

    Also known as: Calcium alpha-ketoglutarate, Ca-AKG

    Calcium salt of α-ketoglutarate; substrate for TCA cycle, cofactor for dioxygenase enzymes (e.g., TET, JmjC), and modulator of epigenetic methylation.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    48/100
    LongevityMitochondrial supportBone healthInflammation
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Calcium alpha-ketoglutarate (Ca-AKG) is a TCA cycle intermediate that has shown lifespan extension in animals and reduces biological age markers in early human studies.

    Mechanism & Function

    Mechanism of Action

    Supports mitochondrial energy, drives collagen and protein synthesis via dioxygenase cofactor role, and modulates epigenetic state.

    Physiological Role

    Used in longevity stacks; early human trial showed 8-year reduction in biological age markers; cellular ageing benefits emerging.

    Primary Pathways

    TCA cycle substrate2-OG-dependent dioxygenase cofactorEpigenetic methylation modulationCollagen synthesis

    Performance / Health Relevance

    Strong preclinical data; emerging human data; small pilot trial showed biological age reductions.

    Evidence Review

    Overall48/100
    Human Clinical40/100
    Meta-AnalysisN/A

    No meta-analyses or systematic reviews indexed for this ingredient yet.

    Mechanistic82/100
    Real-World48/100
    Safety85/100

    Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.

    Compare Calcium Forms

    7 calcium forms are indexed. Bioavailability, clinical evidence, and best-use cases differ meaningfully between them.

    FormEvidence
    Calcium AKGThis page

    Moderate.

    48/100
    Calcium Caseinate

    DIAAS ≈ 1.18; complete EAA profile.

    78/100
    Calcium Citrate

    ~22–27% absorption regardless of stomach acidity.

    75/100
    HMB

    Ca-HMB ~80%; HMB-FA produces 2× higher peak plasma at same dose.

    68/100
    Calcium Carbonate

    Calcium carbonate provides elemental calcium but requires gastric acid for absorption; absorption may be reduced on a completely achlorhydric stomach.

    67/100
    Vitamin B5 (Pantothenic Acid)

    Well-absorbed from the gastrointestinal tract. Bioavailability is generally high.

    65/100
    Calcium Lactate

    One trial measured absorption from a calcium lactate drink; small differences in fractional absorption were observed when additional caseinophosphopeptide preparations were included, but these differences were judged unlikely to be biologically meaningful.

    45/100
    Open full side-by-side comparison

    Practical Use & Dosage

    Minimum Effective Dose
    500 mg/day
    Optimal Range
    1–2 g/day
    Upper / Caution Level
    ~3 g/day
    Timing
    Morning
    Best Format
    Capsule, powder
    Bioavailability
    Moderate.
    Absorption Considerations
    Standard intestinal absorption.

    Safety & Interactions

    Side Effects

    • •Mild GI upset

    Contraindications

    • Hypercalcaemia

    Drug Interactions

    • •Tetracyclines
    • •Bisphosphonates
    • •Quinolones (calcium content)

    Who Should Avoid

    • •Severe renal impairment

    Monitoring

    None routine.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Calcium AKG typically used or indicated?

    Calcium AKG is most commonly used for: Longevity, Mitochondrial support, Bone health, Inflammation. Used in longevity stacks; early human trial showed 8-year reduction in biological age markers; cellular ageing benefits emerging.

    How does Calcium AKG work?

    Supports mitochondrial energy, drives collagen and protein synthesis via dioxygenase cofactor role, and modulates epigenetic state.

    What is the recommended dose of Calcium AKG?

    The optimal range is 1–2 g/day. with a minimum effective dose of 500 mg/day. Best taken: Morning. Upper / caution level: ~3 g/day.

    What are the side effects of Calcium AKG?

    Reported side effects include: Mild GI upset. Monitoring: None routine.

    Does Calcium AKG interact with medications?

    Known or theoretical interactions: Tetracyclines; Bisphosphonates; and Quinolones (calcium content). Always check with a clinician before combining with prescription medication.

    Who should avoid Calcium AKG?

    Calcium AKG is generally not recommended for: Severe renal impairment; and Hypercalcaemia.

    How strong is the evidence for Calcium AKG?

    Evidence level: Limited (overall score 48/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Calcium alpha-ketoglutarate on biological ageing markers

    Observational2021Low
    PubMed

    Average 8-year reduction in DNAmAge GrimAge metric.

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    Research Overview

    Limited Evidence
    1Total Studies
    1Human Trials
    0Meta-Analyses
    2021Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceMixed
    Pooled evidence (meta-analysis / systematic review)No

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/calcium-akg

    SuppIndex. (2026). Calcium AKG: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/calcium-akg

    Based on 1 indexed studies · Evidence level: Limited.

    Goal Ratings

    General Health
    Recovery
    Endurance

    Stack Compatibility

    Pair with NMN, glycine, collagen.

    NMNGlycineCollagen