Yohimbine
Also known as: Yohimbe, 8α-17α-estryloyohimbine
A 1998 meta-analysis of randomized controlled trials found yohimbine superior to placebo for erectile dysfunction with few serious adverse reactions reported. Later reviews place yohimbine among various treatments for erectile dysfunction, while evidence for use as an antidepressant augmentation strategy is not supportive in the reviewed literature.
Last reviewed: 2026-10-14 · 3 indexed studies
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Overview
Yohimbine is an alkaloid traditionally used for sexual dysfunction and marketed in some regions as a dietary supplement. Clinical trial evidence in humans is mixed but there is meta-analytic evidence of benefit for erectile dysfunction; other indications lack convincing human data in the provided abstracts.
Mechanism & Function
Mechanism of Action
Mechanistic details are not described in the provided abstracts; the clinical literature in these abstracts reports on symptomatic outcomes rather than mechanisms.
Physiological Role
Not detailed in the provided abstracts.
Primary Pathways
Performance / Health Relevance
Limited evidence for athletic performance in the supplied abstracts; the included systematic review of supplements mentions yohimbine among many agents but does not provide direct trial-level evidence of performance benefit in the excerpts provided.
Evidence Review
Practical Use & Dosage
- Minimum Effective Dose
- Not established in the provided abstracts
- Optimal Range
- Not established in the provided abstracts
- Upper / Caution Level
- Not established in the provided abstracts
- Timing
- Not established in the provided abstracts
- Best Format
- Not established in the provided abstracts
- Bioavailability
- Not established in the provided abstracts
- Absorption Considerations
- Not established in the provided abstracts
Safety & Interactions
Side Effects
- •Adverse reactions reported as infrequent and reversible in the 1998 meta-analysis
- •Specific adverse events not detailed in the provided abstracts
Contraindications
- Not detailed in the provided abstracts
Drug Interactions
- •Not detailed in the provided abstracts
Who Should Avoid
- •Not specified in the provided abstracts
Monitoring
Not detailed in the provided abstracts; clinical trials reported adverse events but did not provide monitoring protocols in the provided excerpts.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Yohimbine typically used or indicated?
Yohimbine is most commonly used for: Erectile dysfunction / sexual performance, Weight loss / fat loss (traditional use), Adjunctive treatment in psychiatric conditions (investigational). Not detailed in the provided abstracts.
How does Yohimbine work?
Mechanistic details are not described in the provided abstracts; the clinical literature in these abstracts reports on symptomatic outcomes rather than mechanisms.
What is the recommended dose of Yohimbine?
The optimal range is Not established in the provided abstracts. with a minimum effective dose of Not established in the provided abstracts. Best taken: Not established in the provided abstracts. Upper / caution level: Not established in the provided abstracts.
What are the side effects of Yohimbine?
Reported side effects include: Adverse reactions reported as infrequent and reversible in the 1998 meta-analysis; and Specific adverse events not detailed in the provided abstracts. Monitoring: Not detailed in the provided abstracts; clinical trials reported adverse events but did not provide monitoring protocols in the provided excerpts.
Does Yohimbine interact with medications?
Known or theoretical interactions: Not detailed in the provided abstracts. Always check with a clinician before combining with prescription medication.
Who should avoid Yohimbine?
Yohimbine is generally not recommended for: Not specified in the provided abstracts; and Not detailed in the provided abstracts.
How strong is the evidence for Yohimbine?
Evidence level: Limited (overall score 48/100), based on 3 indexed studies on SuppIndex.
Research & References (3)
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of randomized, placebo-controlled trials of yohimbine monotherapy for erectile dysfunction (seven trials).
Erectile dysfunction.
Broad systematic review of interventions for erectile dysfunction which includes discussion of yohimbine among other treatments.
A systematic review of augmentation strategies for patients with major depressive disorder.
Systematic review of augmentation strategies for major depressive disorder that considered a range of agents including yohimbine.
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Research Overview
Limited EvidenceCite this ingredient
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Stable URL
https://thesuppindex.com/ingredients/yohimbine
SuppIndex. (2026). Yohimbine: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/yohimbine
Based on 3 indexed studies · Evidence level: Limited.
Goal Ratings
Stack Compatibility
Not detailed in the provided abstracts.