Ubiquinol
Also known as: Coenzyme Q10 (reduced form), CoQ10 (ubiquinol)
Randomized trials in the provided abstracts report that ubiquinol (150–600 mg/day) reduced symptoms and increased ejection fraction in patients with HFpEF, improved some symptoms and cognitive/autonomic measures in chronic fatigue syndrome, and modulated markers of energy metabolism and bone formation during strenuous exercise. A randomized trial found no benefit of ubiquinol (600 mg/day) for statin-associated muscle pain. One included review was not an intervention trial and was marked irrelevant for supplementation evidence.
Last reviewed: 2026-10-14 · 4 indexed studies
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Overview
Ubiquinol is the reduced, active form of coenzyme Q10 commonly sold as an oral supplement. Human trials have tested daily doses typically between 150 mg and 600 mg for conditions including heart failure with preserved ejection fraction, chronic fatigue syndrome and exercise-related outcomes.
Mechanism & Function
Mechanism of Action
Human studies in the abstracts relate ubiquinol to alterations in mitochondrial-related biomarkers, energy metabolism and indicators of cardiac function, suggesting effects on cellular energy handling and related physiological processes.
Physiological Role
Participates in mitochondrial energy metabolism and is associated with biomarkers of cellular energy status and cardiac performance in the cited trials.
Primary Pathways
Performance / Health Relevance
Short-term supplementation altered biochemical markers linked to energy mobilisation and increased markers of bone formation in a strenuous exercise model, which the authors suggest could confer an ergogenic advantage; direct improvements in physical performance measures were not consistently reported in these abstracts.
Evidence Review
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- 150 mg/day (seen in an RCT reporting benefit in chronic fatigue syndrome)
- Optimal Range
- 150–600 mg/day (doses used across trials)
- Upper / Caution Level
- Not established from these abstracts (trials used up to 600 mg/day)
- Timing
- Daily
- Best Format
- Oral ubiquinol (reduced CoQ10) capsules or softgels as used in trials
- Bioavailability
- Not established in these abstracts.
- Absorption Considerations
- Not established in these abstracts.
Safety & Interactions
Side Effects
- •One trial reported a marginally higher number of subjects reporting muscle pain with ubiquinol versus placebo in people taking simvastatin
- •No major adverse events were highlighted in the provided abstracts
Contraindications
- Not established in these abstracts
Drug Interactions
- •Insufficient data in these abstracts to define specific interactions
Who Should Avoid
- •Not established in these abstracts
Monitoring
Clinical monitoring and standard medical oversight advised when using alongside prescription therapies; specific monitoring was not detailed in the abstracts.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Ubiquinol typically used or indicated?
Ubiquinol is most commonly used for: General mitochondrial support, Heart failure adjunctive therapy, Support for chronic fatigue symptoms, Exercise recovery / performance modulation. Participates in mitochondrial energy metabolism and is associated with biomarkers of cellular energy status and cardiac performance in the cited trials.
How does Ubiquinol work?
Human studies in the abstracts relate ubiquinol to alterations in mitochondrial-related biomarkers, energy metabolism and indicators of cardiac function, suggesting effects on cellular energy handling and related physiological processes.
What is the recommended dose of Ubiquinol?
The optimal range is 150–600 mg/day (doses used across trials). with a minimum effective dose of 150 mg/day (seen in an RCT reporting benefit in chronic fatigue syndrome). Best taken: Daily. Upper / caution level: Not established from these abstracts (trials used up to 600 mg/day).
What are the side effects of Ubiquinol?
Reported side effects include: One trial reported a marginally higher number of subjects reporting muscle pain with ubiquinol versus placebo in people taking simvastatin; and No major adverse events were highlighted in the provided abstracts. Monitoring: Clinical monitoring and standard medical oversight advised when using alongside prescription therapies; specific monitoring was not detailed in the abstracts.
Does Ubiquinol interact with medications?
Known or theoretical interactions: Insufficient data in these abstracts to define specific interactions. Always check with a clinician before combining with prescription medication.
Who should avoid Ubiquinol?
Ubiquinol is generally not recommended for: Not established in these abstracts; and Not established in these abstracts.
How strong is the evidence for Ubiquinol?
Evidence level: Moderate (overall score 66/100), based on 4 indexed studies on SuppIndex.
Research & References (4)
A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy.
Randomized, double-blind trial in patients with confirmed statin myopathy comparing simvastatin plus ubiquinol 600 mg/day versus simvastatin plus placebo for 8 weeks.
Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction.
Phase 2 randomized, double-blind, placebo-controlled trial of ubiquinol and/or d-ribose in 216 patients with heart failure with preserved ejection fraction (HFpEF) over 12 weeks.
Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.
Open-label and randomized, double-blind, placebo-controlled trial of ubiquinol-10 (150 mg/day) in patients with chronic fatigue syndrome (CFS); 31 subjects completed the randomized phase.
Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
Randomized trial in 100 healthy, well-trained firemen comparing ubiquinol 200 mg/day versus placebo for two weeks, assessing effects on energy metabolism and bone turnover during repeated strenuous exercise.
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Research Overview
Moderate EvidenceCite this ingredient
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Stable URL
https://thesuppindex.com/ingredients/ubiquinol
SuppIndex. (2026). Ubiquinol: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/ubiquinol
Based on 4 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
One trial assessed ubiquinol together with d-ribose for HFpEF; other combination data are not provided in these abstracts.