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    Trademarks/Nitrosigine®/Nitrosigine®
    Nitrosigine® branded ingredient logo by Nutrition21
    Trademarked IngredientPump and Performance Ingredients

    Nitrosigine®

    A trademarked form of Nitrosigine®

    Parent Evidence
    82/100

    Manufacturer

    Nutrition21

    Clinical Studies

    6

    Certifications

    6

    Purity

    Standard

    Last reviewed: 2024-08-01

    Technical Specifications

    Clinical Evidence

    2 trademark-specific studies · 6 parent (generic Nitrosigine®) studies shown for context

    1
    Nitrosigine-specific evidence

    Nitrosigine® supplementation improves cognitive function during acute exercise (2021)

    Improved cognitive flexibility and processing speed during and post-exercise; attributed to enhanced cerebral blood flow.

    PubMed 33924655
    2
    Nitrosigine-specific evidence

    Safety assessment of inositol-stabilized arginine silicate (ASI; Nitrosigine®) (2020)

    No clinically significant adverse events; GRAS status confirmed for doses up to 1500mg/day.

    3
    Parent / generic Nitrosigine® evidence

    30+ published clinical studies

    4
    Parent / generic Nitrosigine® evidence

    Sustained arginine elevation for 6 hours (single dose)

    5
    Parent / generic Nitrosigine® evidence

    Cognitive performance enhancement during exercise (RCT)

    6
    Parent / generic Nitrosigine® evidence

    Flow-mediated dilation (FMD) improvement

    7
    Parent / generic Nitrosigine® evidence

    Post-exercise muscle blood volume enhancement

    8
    Parent / generic Nitrosigine® evidence

    19 U.S. and international patents

    Frequently Asked Questions

    What is Nitrosigine?

    Nitrosigine® is a trademarked form of Nitrosigine® manufactured by Nutrition21.

    Who makes Nitrosigine?

    Nitrosigine is made by Nutrition21.

    How much clinical evidence does Nitrosigine have?

    SuppIndex lists 6 clinical studies for Nitrosigine and 6 certifications (GRAS Self-Affirmed, Non-GMO, Vegan, Allergen-Free, NDI Filed, Informed Sport Certified). The parent ingredient Nitrosigine® has an overall evidence score of 82/100 (Strong).

    Parent Ingredient

    Nitrosigine®

    Inositol-stabilized arginine silicate complex that provides sustained elevation of plasma arginine (up to 6 hours) and silicon, enhancing eNOS-mediated nitric oxide production, vascular compliance, and cognitive flexibility during physical exertion.

    Nitric oxide enhancementPre-workout vasodilationCognitive focus during trainingSustained blood flow

    View the parent ingredient page for full evidence review, dosage guidance, mechanism of action, and safety information.

    Products Using Nitrosigine®

    Kaged

    Pre-Kaged Elite

    $49.99
    1500mg Nitrosigine® · 1 scoop
    4.8

    Ghost

    Ghost Legend V3

    $44.99
    1500mg Nitrosigine® · 1 scoop
    4.7

    Transparent Labs

    BULK Black Pre-Workout

    $54.99
    1500mg Nitrosigine® · 1 scoop
    4.7

    Huge Supplements

    Pump Serum

    $44.95
    1500mg Nitrosigine® · 1 scoop
    4.6

    Manufacturer

    Nitrosigine® branded ingredient logo by Nutrition21

    Nutrition21

    Website Contact

    Certifications (6)

    GRAS Self-Affirmed
    Non-GMO
    Vegan
    Allergen-Free
    NDI Filed
    Informed Sport Certified

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