MAX Catalyst®
A trademarked form of Piperine
MAX Catalyst® is a next-generation, water-soluble piperine technology developed by UseTheMAX, LLC. Standard crystalline piperine is highly hydrophobic (aqueous solubility ≈0.04 mg/mL), which has historically limited piperine to capsules and tablets. MAX Catalyst's morphology-modified particles disperse in water under gravity alone — enabling the first commercially viable use of piperine in RTD beverages, stick packs, and liquid shots. The brand's 2024 randomized, double-blind, crossover human clinical program tested 2 mg of MAX Catalyst against control across 32+ ingredients at consumer-realistic doses, producing the largest published bioavailability dataset for any single bioenhancer.
Manufacturer
UseTheMAX, LLC
Clinical Studies
33
Certifications
8
Purity
≥95% piperine, standardised; characterised by FTIR + HPLC
Last reviewed: 2024-09-01
What Makes It Different
The first water-soluble piperine validated for ready-to-drink (RTD), stick-pack, and liquid-shot formats. Modified particle morphology (confirmed by Zeiss Gemini 300 FE-SEM) yields a dramatically higher surface-area-to-volume ratio than standard crystalline piperine, enabling rapid dispersion in water (vs standard piperine's 0.04 mg/mL solubility) and the highest published bioavailability gains for any piperine technology — head-to-head wins vs BioPerine® across every co-tested ingredient (e.g. CoQ10 +580% vs +32%, Vitamin C +68.3% vs +39.2%, Vitamin A +150% vs 0%, B6 +128.6% vs +77.9%).
Technical Specifications
Ingredient Type
Enhanced water-soluble piperine (modified particle morphology)
Purity / Standardisation
≥95% piperine, standardised; characterised by FTIR + HPLC
Brand Owner
UseTheMAX, LLC
Country of Origin
USA (St. Petersburg, FL)
Claims & Positioning
First and only water-soluble piperine validated for RTD, stick-pack, and liquid-shot formats
Largest published bioavailability dataset for a single bioenhancer (32+ ingredients, multiple independent US CROs)
Outperforms BioPerine® head-to-head on every co-tested ingredient
Significantly improves intracellular piperine uptake vs standard piperine
32+ optional MAXed™ co-branded ingredient marks (MAXed Creatine®, MAXed Citrulline™, MAXed Electrolytes™, etc.) for premium positioning
Consumer research: 74% of sports-nutrition buyers prefer a more expensive MAXed product over standard equivalents
Inherits piperine's 30+ year GRAS-equivalent safety history; no adverse events at 2 mg in the trial program
Clinical Evidence
2 trademark-specific studies · 18 parent (generic Piperine) studies shown for context
Intracellular piperine uptake: MAX Catalyst +20 vs control −20 (baseline-adjusted, human cells)
MAX Catalyst randomized, double-blind, crossover human clinical trials on 32+ ingredients (2024)
Significant bioavailability increases across all tested ingredients; greatest effects for minerals and fat-soluble compounds.
Randomized, double-blind, crossover human clinical trial on 32+ ingredients (multiple independent CROs: Keiser University, ASPI Labs, Kutztown University, University of Tampa, 2024)
Vitamin C absorption: +68.33% (vs BioPerine® +39.2%)
CoQ10 absorption: +580% (vs BioPerine® +32%)
Vitamin A absorption: +150% (vs BioPerine® 0%)
Beta-Carotene absorption: +64.71% (vs BioPerine® +60%)
Vitamin B6 absorption: +128.57% (vs BioPerine® +77.86%)
L-Arginine absorption: +214.29% (head-to-head vs AstraGin® +17.3%)
L-Tyrosine: +475% · L-Carnitine: +177.78% · Alpha-GPC: +290.91% · Choline: +290.91%
Omega-3 DHA: +166.67% · Omega-3 EPA: +566.67%
Creatine: +82.87% · Beta-Alanine: +119.20% · Citrulline: +70.75% · Taurine: +19.69%
Whey Protein: +16.25% · Pea Protein (Methionine): +45.16% · Collagen: +13.17% · EAAs: +14.91% · BCAAs: +18.96%
Calcium: +57.14% · Iron: +185% · Zinc: +3,800% · Electrolytes: +66.49% · Vitamin K: +139.13%
B12: +106.45% · Biotin: +41.18% · B-Complex: +92.86% · Tryptophan: +60.86% · Pycnogenol®: +266.67%
Caffeine (200mg): +47.48% energy, +55.56% focus, +31.58% motivation, −40% jitters, −47.22% crash, +2 hr duration
Beta-Alanine paresthesia tolerability: −14% (reduced tingling at equal dose)
Scanning Electron Microscope morphology analysis (Zeiss Gemini 300 FE-SEM, 20 nm resolution)
Water solubility / RTD compatibility validation (100 mg piperine in 250 mL water, 21.67 °C)
FTIR + HPLC identity & purity protocol (peer-reviewed publication)
Patents & Proprietary Protections
Frequently Asked Questions
What is MAX Catalyst?
MAX Catalyst® is a trademarked form of Piperine manufactured by UseTheMAX, LLC. MAX Catalyst® is a next-generation, water-soluble piperine technology developed by UseTheMAX, LLC. Standard crystalline piperine is highly hydrophobic (aqueous solubility ≈0.04 mg/mL), which has historically limited piperine to capsules and tablets. MAX Catalyst's morphology-modified particles disperse in water under gravity alone — enabling the first commercially viable use of piperine in RTD beverages, stick packs, and liquid shots. The brand's 2024 randomized, double-blind, crossover human clinical program tested 2 mg of MAX Catalyst against control across 32+ ingredients at consumer-realistic doses, producing the largest published bioavailability dataset for any single bioenhancer.
How is MAX Catalyst different from generic Piperine?
The first water-soluble piperine validated for ready-to-drink (RTD), stick-pack, and liquid-shot formats. Modified particle morphology (confirmed by Zeiss Gemini 300 FE-SEM) yields a dramatically higher surface-area-to-volume ratio than standard crystalline piperine, enabling rapid dispersion in water (vs standard piperine's 0.04 mg/mL solubility) and the highest published bioavailability gains for any piperine technology — head-to-head wins vs BioPerine® across every co-tested ingredient (e.g. CoQ10 +580% vs +32%, Vitamin C +68.3% vs +39.2%, Vitamin A +150% vs 0%, B6 +128.6% vs +77.9%).
Who makes MAX Catalyst?
MAX Catalyst is made by UseTheMAX, LLC (USA (St. Petersburg, FL)).
How much clinical evidence does MAX Catalyst have?
SuppIndex lists 33 clinical studies for MAX Catalyst and 8 certifications (GMP Certified, Made in USA, NSF Certified, Gluten-Free, Soy-Free, Kosher, Non-GMO Project Verified, 100% Organic (option)). The parent ingredient Piperine has an overall evidence score of 82/100 (Strong).
Parent Ingredient
Piperine
A piperidine alkaloid (C₁₇H₁₉NO₃) that inhibits cytochrome P450 enzymes (CYP3A4, CYP1A2, CYP2E1), P-glycoprotein efflux transporters, and UDP-glucuronosyltransferases while enhancing intestinal permeability, digestive enzyme secretion, and splanchnic blood flow — collectively producing dramatic improvements in nutrient bioavailability.
View the parent ingredient page for full evidence review, dosage guidance, mechanism of action, and safety information.
Products Using MAX Catalyst®
Common Brands
Manufacturer
UseTheMAX, LLC
USA (St. Petersburg, FL)
Visit WebsiteCertifications (8)
Goal Relevance
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