BioPerine®
A trademarked form of Piperine
BioPerine® is Sabinsa Corporation's standardised black-pepper (Piper nigrum) extract delivering ≥95% piperine. Patented in 1996, it is the most widely used branded bioenhancer in the global supplement industry and remains the default piperine reference in published literature. BioPerine® uses standard crystalline piperine — hydrophobic, formulation-limited to capsules and tablets, and clinically validated on a narrower set of co-administered compounds than newer morphology-modified piperines such as MAX Catalyst®.
Manufacturer
Sabinsa Corporation
Clinical Studies
5
Certifications
5
Purity
≥95% piperine, standardised
Last reviewed: 2016-01-01
What Makes It Different
The original commercially-standardised piperine bioenhancer — patented in 1996 and the most widely cited piperine ingredient in the supplement industry. The published clinical record is centred on a narrow set of co-administered compounds (curcumin, CoQ10, selenium, β-carotene, vitamin B6) at 5 mg doses, with smaller absorption gains than newer morphology-modified piperines and no water-soluble RTD format.
Technical Specifications
Ingredient Type
Standard crystalline piperine (Piper nigrum dried-fruit extract)
Purity / Standardisation
≥95% piperine, standardised
Brand Owner
Sami-Sabinsa Group
Country of Origin
India
Claims & Positioning
Original patented piperine bioenhancer (US Pat. 5,536,506, 1996)
Most widely used branded bioenhancer in the global supplement industry
Clinically validated for curcumin (+2,000%), CoQ10 (+32%), β-carotene (+60%), B6 (+77.9%), Vitamin C (+39.2%)
Self-affirmed GRAS; long market history
Clinical Evidence
0 trademark-specific studies · 7 parent (generic Piperine) studies shown for context
Curcumin: +2,000% serum AUC at 20 mg piperine + 2 g curcumin (Shoba et al., 1998, PMID 9619120)
CoQ10: +32% absorption (head-to-head vs MAX Catalyst® +580%)
Vitamin C: +39.2% absorption (vs MAX Catalyst® +68.33%)
Beta-Carotene: +60% absorption (vs MAX Catalyst® +64.71%)
Vitamin B6 (pyridoxine): +77.86% absorption (vs MAX Catalyst® +128.57%)
Vitamin A absorption: 0% gain (vs MAX Catalyst® +150%)
Selenium absorption studies (Sabinsa internal)
Patents & Proprietary Protections
Frequently Asked Questions
What is BioPerine?
BioPerine® is a trademarked form of Piperine manufactured by Sabinsa Corporation. BioPerine® is Sabinsa Corporation's standardised black-pepper (Piper nigrum) extract delivering ≥95% piperine. Patented in 1996, it is the most widely used branded bioenhancer in the global supplement industry and remains the default piperine reference in published literature. BioPerine® uses standard crystalline piperine — hydrophobic, formulation-limited to capsules and tablets, and clinically validated on a narrower set of co-administered compounds than newer morphology-modified piperines such as MAX Catalyst®.
How is BioPerine different from generic Piperine?
The original commercially-standardised piperine bioenhancer — patented in 1996 and the most widely cited piperine ingredient in the supplement industry. The published clinical record is centred on a narrow set of co-administered compounds (curcumin, CoQ10, selenium, β-carotene, vitamin B6) at 5 mg doses, with smaller absorption gains than newer morphology-modified piperines and no water-soluble RTD format.
Who makes BioPerine?
BioPerine is made by Sabinsa Corporation (India); the brand is owned by Sami-Sabinsa Group.
How much clinical evidence does BioPerine have?
SuppIndex lists 5 clinical studies for BioPerine and 5 certifications (Self-affirmed GRAS, NDI notified (FDA), Non-GMO, Kosher, Halal). The parent ingredient Piperine has an overall evidence score of 82/100 (Strong).
Parent Ingredient
Piperine
A piperidine alkaloid (C₁₇H₁₉NO₃) that inhibits cytochrome P450 enzymes (CYP3A4, CYP1A2, CYP2E1), P-glycoprotein efflux transporters, and UDP-glucuronosyltransferases while enhancing intestinal permeability, digestive enzyme secretion, and splanchnic blood flow — collectively producing dramatic improvements in nutrient bioavailability.
View the parent ingredient page for full evidence review, dosage guidance, mechanism of action, and safety information.
Products Using BioPerine®
Common Brands
Jacked Factory
Growth Surge Post-Workout
Transparent Labs
StrengthSeries Creatine HMB
NOW Foods
Curcumin with BioPerine®
Manufacturer
Sabinsa Corporation
Brand owner: Sami-Sabinsa Group
India
Visit WebsiteCertifications (5)
Goal Relevance
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