Palatinose (Isomaltulose)
Also known as: Isomaltulose, Palatinose
Hydrolysed by intestinal isomaltase ~4–5× slower than sucrose, producing prolonged glycaemia and lower insulin AUC; full caloric value (4 kcal/g).
Last reviewed: 2026-06-23 · 1 indexed study
Set your location for accurate regulatory status
Saved on this device — no sign-in needed.
Overview
Palatinose is a slowly digested disaccharide (glucose+fructose linked α-1,6) yielding a sustained, low glycaemic glucose release ideal for sustained-energy applications and metabolic-health-conscious users.
Mechanism & Function
Mechanism of Action
Acts as a sustained glucose source, preserves fat oxidation during exercise, and lowers postprandial insulin spike compared with sucrose or maltodextrin.
Physiological Role
Useful for endurance athletes seeking flatter glycaemic curve and for metabolic-health applications; supports steady cognitive energy without rebound hypoglycaemia.
Primary Pathways
Performance / Health Relevance
Cycling RCTs show preserved fat oxidation and improved late-stage performance vs sucrose; equally hydrating with lower insulin spike.
Evidence Review
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- 15 g pre-exercise
- Optimal Range
- 30–60 g/hour during long endurance
- Upper / Caution Level
- ~90 g/hour (often co-ingested with fast carbs)
- Timing
- 30–45 min pre-exercise or intra
- Best Format
- Powder, often 50:50 with HBCD/maltodextrin
- Bioavailability
- Complete digestion but at slow rate; ~70% of glucose AUC of sucrose.
- Absorption Considerations
- Standard SGLT1 transport for the glucose moiety; fructose via GLUT5.
Safety & Interactions
Side Effects
- •Possible bloating at high single doses
Contraindications
- Hereditary fructose intolerance
Drug Interactions
- •Insulin (dose timing)
Who Should Avoid
- •Those with fructose malabsorption
Monitoring
None routinely.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Palatinose (Isomaltulose) typically used or indicated?
Palatinose (Isomaltulose) is most commonly used for: Low-glycaemic carbohydrate, Sustained-energy fuel, Fat-oxidation friendly carb, Diabetic-suitable sweetener. Useful for endurance athletes seeking flatter glycaemic curve and for metabolic-health applications; supports steady cognitive energy without rebound hypoglycaemia.
How does Palatinose (Isomaltulose) work?
Acts as a sustained glucose source, preserves fat oxidation during exercise, and lowers postprandial insulin spike compared with sucrose or maltodextrin.
What is the recommended dose of Palatinose (Isomaltulose)?
The optimal range is 30–60 g/hour during long endurance. with a minimum effective dose of 15 g pre-exercise. Best taken: 30–45 min pre-exercise or intra. Upper / caution level: ~90 g/hour (often co-ingested with fast carbs).
What are the side effects of Palatinose (Isomaltulose)?
Reported side effects include: Possible bloating at high single doses. Monitoring: None routinely.
Does Palatinose (Isomaltulose) interact with medications?
Known or theoretical interactions: Insulin (dose timing). Always check with a clinician before combining with prescription medication.
Who should avoid Palatinose (Isomaltulose)?
Palatinose (Isomaltulose) is generally not recommended for: Those with fructose malabsorption; and Hereditary fructose intolerance.
How strong is the evidence for Palatinose (Isomaltulose)?
Evidence level: Moderate (overall score 68/100), based on 1 indexed study on SuppIndex.
Research & References (1)
Isomaltulose improves fat oxidation during endurance exercise compared with sucrose
Isomaltulose preserved fat oxidation (+18%) and produced equal performance with lower glycaemic excursion.
Trademark Ingredients
Related Ingredients
Other top-rated ingredients in Ergogenic Compounds.
Creatine Monohydrate
94/100A naturally occurring nitrogenous organic acid that facilitates recycling of adenosine triphosphate (ATP) in muscle and brain tissue via the phosphocreatine shuttle.
Maltodextrin
78/100Short-chain α-1,4 linked glucose polymer that is rapidly hydrolysed by brush-border maltase to glucose; near-equivalent glycaemic response to glucose but lower osmolality at concentration.
Cyclic Dextrin (HBCD)
72/100Produced via cyclic-glucanotransferase action on amylopectin, HBCD forms cluster-like macromolecules ~160 kDa that solubilise at low osmolality (≈4 mOsm/L) and clear the stomach faster than maltodextrin or glucose polymers.
Research Overview
Moderate EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/palatinose
SuppIndex. (2026). Palatinose (Isomaltulose): Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/palatinose
Based on 1 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
Combine with HBCD or maltodextrin for blended fast+slow carb fuel; pair with electrolytes.