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    Botanical ExtractsNatural

    Juglans Regia Extract

    Also known as: Walnut leaf extract, Juglans regia, Juglone

    Walnut leaf and hull extract; provides juglone and proposed PEA-precursor alkaloids; mechanism in supplements is debated.

    Last reviewed: 2026-06-23 · 1 indexed study

    Evidence Score
    34/100
    StimulantMoodPre-workout energy
    Data Completeness3/4 · 75%
    Evidence ScoreDosageSafetyLinked Studies

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    Overview

    Juglans regia (English walnut) leaf extract provides a complex of alkaloids including precursors to phenylethylamine derivatives used as natural pre-workout stimulants.

    Mechanism & Function

    Mechanism of Action

    Proposed catecholamine and trace-amine modulation; some products may be spiked with synthetic actives — quality control is critical.

    Physiological Role

    Used in pre-workouts for mood/focus; reliability depends heavily on supplier; some commercial extracts have been adulterated.

    Primary Pathways

    Possible TAAR1 modulationTrace amine precursor

    Performance / Health Relevance

    Limited high-quality clinical data; mechanistic claims often outpace evidence.

    Evidence Review

    Overall34/100
    Human Clinical25/100
    Meta-Analysis15/100
    Mechanistic60/100
    Real-World40/100
    Safety62/100

    Practical Use & Dosage

    Minimum Effective Dose
    50 mg
    Optimal Range
    100–250 mg pre-workout
    Upper / Caution Level
    ~500 mg
    Timing
    Pre-exercise
    Best Format
    Capsule, powder
    Bioavailability
    Unknown.
    Absorption Considerations
    Mixed; quality-dependent.

    Safety & Interactions

    Side Effects

    • •Mild headache
    • •BP elevation
    • •GI upset

    Contraindications

    • Walnut allergy
    • Pregnancy
    • Cardiovascular disease

    Drug Interactions

    • •MAOIs
    • •Stimulants
    • •Antihypertensives

    Who Should Avoid

    • •Pregnancy
    • •Anxiety disorders

    Monitoring

    BP, HR.

    Frequently Asked Questions

    Auto-generated from indexed evidence — dosage, safety, interactions, and more.

    When is Juglans Regia Extract typically used or indicated?

    Juglans Regia Extract is most commonly used for: Stimulant, Mood, Pre-workout energy. Used in pre-workouts for mood/focus; reliability depends heavily on supplier; some commercial extracts have been adulterated.

    How does Juglans Regia Extract work?

    Proposed catecholamine and trace-amine modulation; some products may be spiked with synthetic actives — quality control is critical.

    What is the recommended dose of Juglans Regia Extract?

    The optimal range is 100–250 mg pre-workout. with a minimum effective dose of 50 mg. Best taken: Pre-exercise. Upper / caution level: ~500 mg.

    What are the side effects of Juglans Regia Extract?

    Reported side effects include: Mild headache; BP elevation; and GI upset. Monitoring: BP, HR.

    Does Juglans Regia Extract interact with medications?

    Known or theoretical interactions: MAOIs; Stimulants; and Antihypertensives. Always check with a clinician before combining with prescription medication.

    Who should avoid Juglans Regia Extract?

    Juglans Regia Extract is generally not recommended for: Pregnancy; Anxiety disorders; Walnut allergy; Pregnancy; and Cardiovascular disease.

    How strong is the evidence for Juglans Regia Extract?

    Evidence level: Preliminary (overall score 34/100), based on 1 indexed study on SuppIndex.

    Research & References (1)

    Walnut leaf extract and trace amine pharmacology: review

    Systematic Review2019Low

    Limited high-quality clinical data; product adulteration concerns documented.

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    Research Overview

    Preliminary Evidence
    1Total Studies
    0Human Trials
    0Meta-Analyses
    2019Latest Study
    0Animal / In Vitro
    0Athlete Studies
    Primary data sourceMixed
    Pooled evidence (meta-analysis / systematic review)Yes

    Cite this ingredient

    One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.

    Stable URL

    https://thesuppindex.com/ingredients/juglans-regia-extract

    SuppIndex. (2026). Juglans Regia Extract: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/juglans-regia-extract

    Based on 1 indexed studies · Evidence level: Preliminary.

    Goal Ratings

    Focus
    Stress
    Endurance

    Stack Compatibility

    Common with caffeine in pre-workouts; verify supplier quality and absence of spiking.

    Caffeine AnhydrousL-TyrosineHordenine