Hesperidin
Also known as: hesperidin dihydrochalcone (related), hesperetin glycoside
Multiple systematic reviews and meta‑analyses of randomized controlled trials report that hesperidin supplementation is associated with reductions in LDL cholesterol, total cholesterol and triglycerides in pooled analyses, while pooled data show no consistent benefit for glycaemic control. Evidence for other indications (for example rheumatoid arthritis or non‑alcoholic fatty liver disease) is limited and comes from single RCTs within broader polyphenol reviews, so benefits are uncertain.
Last reviewed: 2026-10-14 · 4 indexed studies
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Overview
Hesperidin is a citrus‑derived flavonoid commonly used in supplements for general cardiovascular and metabolic health. Clinical meta‑analyses of randomized trials report modest improvements in certain blood lipid measures but no clear effect on blood glucose control; safety signals in trials have been minimal.
Mechanism & Function
Mechanism of Action
Clinical reviews and preclinical literature propose antioxidant and anti‑inflammatory effects of hesperidin and modulation of lipid metabolism; these mechanisms could plausibly underlie the modest lipid‑lowering effects seen in pooled trials.
Physiological Role
Exogenous flavonoid with antioxidant and anti‑inflammatory activity; does not have an established essential physiological nutrient role in humans.
Primary Pathways
Performance / Health Relevance
Hesperidin is not an ergogenic compound. Any relevance to performance would be indirect via improvements in general cardiovascular or metabolic markers rather than acute performance enhancement.
Evidence Review
Practical Use & Dosage
- Minimum Effective Dose
- Not established from provided abstracts (clinical trials used a range of doses)
- Optimal Range
- Not established
- Upper / Caution Level
- Not established
- Timing
- Not established
- Best Format
- Oral (supplement capsule/tablet)
- Bioavailability
- Hesperidin is a glycosylated flavonoid; bioavailability can be limited compared with aglycones (not quantified in the provided abstracts).
- Absorption Considerations
- Not established in provided abstracts
Safety & Interactions
Side Effects
- •No increased adverse events reported in pooled analyses of trials (per abstracts)
Contraindications
- Not established in provided abstracts
Drug Interactions
- •Not established in provided abstracts
Who Should Avoid
- •Not established in provided abstracts (insufficient data in pregnant or lactating people and many clinical populations)
Monitoring
Monitor standard clinical markers relevant to the intended use (for example lipid panel) when using for cardiometabolic goals; formal monitoring recommendations not provided in the abstracts.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Hesperidin typically used or indicated?
Hesperidin is most commonly used for: Cardiovascular risk factor support, Antioxidant/anti-inflammatory supplement, Support for metabolic health conditions such as NAFLD. Exogenous flavonoid with antioxidant and anti‑inflammatory activity; does not have an established essential physiological nutrient role in humans.
How does Hesperidin work?
Clinical reviews and preclinical literature propose antioxidant and anti‑inflammatory effects of hesperidin and modulation of lipid metabolism; these mechanisms could plausibly underlie the modest lipid‑lowering effects seen in pooled trials.
What is the recommended dose of Hesperidin?
The optimal range is Not established. with a minimum effective dose of Not established from provided abstracts (clinical trials used a range of doses). Best taken: Not established. Upper / caution level: Not established.
What are the side effects of Hesperidin?
Reported side effects include: No increased adverse events reported in pooled analyses of trials (per abstracts). Monitoring: Monitor standard clinical markers relevant to the intended use (for example lipid panel) when using for cardiometabolic goals; formal monitoring recommendations not provided in the abstracts.
Does Hesperidin interact with medications?
Known or theoretical interactions: Not established in provided abstracts. Always check with a clinician before combining with prescription medication.
Who should avoid Hesperidin?
Hesperidin is generally not recommended for: Not established in provided abstracts (insufficient data in pregnant or lactating people and many clinical populations); and Not established in provided abstracts.
How strong is the evidence for Hesperidin?
Evidence level: Moderate (overall score 55/100), based on 4 indexed studies on SuppIndex.
Research & References (4)
Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta‑analysis of 9 randomized controlled trials (up to April 2023) assessing hesperidin in cardiovascular/metabolic contexts.
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.
Systematic review and meta‑analysis of randomized clinical trials up to February 2019 assessing hesperidin and blood glucose control.
Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Systematic review and meta‑analysis of dietary polyphenols in non‑alcoholic fatty liver disease including hesperidin among studied compounds.
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials.
Systematic review and meta‑analysis of dietary polyphenols for rheumatoid arthritis including a single RCT of hesperidin.
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Piperine
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CoQ10
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Beta-Glucan (Oat)
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Research Overview
Moderate EvidenceCite this ingredient
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Stable URL
https://thesuppindex.com/ingredients/hesperidin
SuppIndex. (2026). Hesperidin: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/hesperidin
Based on 4 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
Often studied as a single flavonoid; trials also appear within multi‑polyphenol interventions. No specific contraindicated stacks reported in the provided abstracts.