Garlic Extract (Aged)
Also known as: Aged garlic extract, AGE, Aged black garlic extract, S-allyl-cysteine (SAC) (constituent)
Randomized trials and meta‑analyses indicate AGE can reduce systolic and diastolic blood pressure in people with hypertension (effects generally modest and more consistent at higher AGE doses) and that AGE may lower circulating CRP and TNF‑α and improve certain innate immune cell functions. Results are heterogeneous and some endpoints show only small changes.
Last reviewed: 2026-10-14 · 4 indexed studies
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Overview
Aged garlic extract (AGE) is a processed form of Allium sativum in which ageing increases stable compounds such as S‑allyl‑cysteine (SAC). Clinical trials and meta‑analyses report modest reductions in blood pressure in people with hypertension and some improvements in inflammatory markers and measures of immune cell function.
Mechanism & Function
Mechanism of Action
AGE contains stable organosulfur compounds such as S‑allyl‑cysteine that have antioxidant properties, modulate nitric oxide availability, and may inhibit angiotensin‑converting enzyme activity; AGE has also been reported to enhance activation and proliferation of innate lymphocytes (γδ‑T and NK cells) in human studies.
Physiological Role
Modulates vascular tone via NO and ACE activity, exerts antioxidant effects, and influences innate immune cell activation.
Primary Pathways
Performance / Health Relevance
Not primarily an ergogenic supplement. Relevant to general cardiovascular health and immune resilience rather than direct exercise performance.
Evidence Review
Practical Use & Dosage
- Minimum Effective Dose
- Evidence suggests effects on blood pressure are more likely at doses ≥ 1,200 mg/day AGE in pooled analyses; single trials of immune outcomes used 2.56 g/day AGE.
- Optimal Range
- Approximately 1,200–2,560 mg AGE per day in published trials, depending on outcome studied.
- Upper / Caution Level
- Not established from provided abstracts; specific upper limits not defined in these sources.
- Timing
- Daily supplementation as used in trials.
- Best Format
- Aged garlic extract capsules (standardised to AGE/SAC when specified).
- Bioavailability
- S‑allyl‑cysteine is a stable AGE constituent used as a marker of AGE content in some trials.
- Absorption Considerations
- Not specifically detailed in the provided abstracts.
Safety & Interactions
Side Effects
- •Generally reported as well tolerated in trials; specific adverse events not detailed in the provided abstracts.
Contraindications
- Caution with anticoagulant or antiplatelet therapy (potential for increased bleeding risk) — consider monitoring.
Drug Interactions
- •Potential interaction with anticoagulant/antiplatelet drugs (based on general guidance rather than the provided abstracts).
Who Should Avoid
- •People on anticoagulant therapy or with bleeding disorders without medical advice
- •Individuals awaiting surgery should discuss use with their clinician.
Monitoring
When used with antihypertensive agents, monitor blood pressure; if combined with anticoagulants, monitor coagulation parameters or seek medical advice.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Garlic Extract (Aged) typically used or indicated?
Garlic Extract (Aged) is most commonly used for: Support for blood pressure in hypertensive individuals, General cardiovascular risk marker modulation, Immune support and reduction of cold/flu symptom severity. Modulates vascular tone via NO and ACE activity, exerts antioxidant effects, and influences innate immune cell activation.
How does Garlic Extract (Aged) work?
AGE contains stable organosulfur compounds such as S‑allyl‑cysteine that have antioxidant properties, modulate nitric oxide availability, and may inhibit angiotensin‑converting enzyme activity; AGE has also been reported to enhance activation and proliferation of innate lymphocytes (γδ‑T and NK cells) in human studies.
What is the recommended dose of Garlic Extract (Aged)?
The optimal range is Approximately 1,200–2,560 mg AGE per day in published trials, depending on outcome studied.. with a minimum effective dose of Evidence suggests effects on blood pressure are more likely at doses ≥ 1,200 mg/day AGE in pooled analyses; single trials of immune outcomes used 2.56 g/day AGE.. Best taken: Daily supplementation as used in trials.. Upper / caution level: Not established from provided abstracts; specific upper limits not defined in these sources..
What are the side effects of Garlic Extract (Aged)?
Reported side effects include: Generally reported as well tolerated in trials; specific adverse events not detailed in the provided abstracts.. Monitoring: When used with antihypertensive agents, monitor blood pressure; if combined with anticoagulants, monitor coagulation parameters or seek medical advice.
Does Garlic Extract (Aged) interact with medications?
Known or theoretical interactions: Potential interaction with anticoagulant/antiplatelet drugs (based on general guidance rather than the provided abstracts).. Always check with a clinician before combining with prescription medication.
Who should avoid Garlic Extract (Aged)?
Garlic Extract (Aged) is generally not recommended for: People on anticoagulant therapy or with bleeding disorders without medical advice; Individuals awaiting surgery should discuss use with their clinician.; and Caution with anticoagulant or antiplatelet therapy (potential for increased bleeding risk) — consider monitoring..
How strong is the evidence for Garlic Extract (Aged)?
Evidence level: Moderate (overall score 70/100), based on 4 indexed studies on SuppIndex.
Research & References (4)
Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial.
Randomized, triple‑blind, placebo‑controlled trial in Grade I hypertensive patients on antihypertensive drugs using an optimized aged black garlic extract providing 0.25 mg/day S‑allyl‑cysteine for 12 weeks.
Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta‑analysis of 9 RCTs (584 participants) examining AGE effects on blood pressure in hypertensive patients; searched to August 2024.
Aged Garlic Extract Modifies Human Immunity.
Randomized, double‑blind, placebo‑controlled parallel trial in healthy adults consuming 2.56 g AGE/day for 90 days during the cold and flu season; assessed innate immune cell function and illness severity.
Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta‑analysis of 17 RCTs to February 2019 on garlic supplementation and inflammatory biomarkers, with subgroup analyses including AGE.
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Research Overview
Moderate EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/garlic-extract-aged
SuppIndex. (2026). Garlic Extract (Aged): Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/garlic-extract-aged
Based on 4 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
AGE has been trialled alongside antihypertensive drug therapy and provided modest additional blood pressure reduction in that context.