Creatine Nitrate
Also known as: CrN, CrNitrate
Randomized human trials report modest, inconsistent ergogenic effects. Short-term (5–28 day) supplementation at ~3–6 g/day produced some improvements in 1RM strength and bench press volume in some trials, while several studies found no consistent effect on sprint or time-trial cycling performance. Creatine nitrate raised plasma nitrate acutely in at least one trial. Multi-ingredient pre-workout studies containing 2 g creatine nitrate showed improved perceptions and some cognitive test changes but cannot isolate the effect of creatine nitrate.
Last reviewed: 2026-10-14 · 5 indexed studies
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Overview
Creatine nitrate is a form of creatine in which a nitrate moiety is bound to creatine, sold in powders and pre-workout formulas. Human trials to date are short term and have tested daily doses in the ~1.5–6 g range, either alone or as part of multi-ingredient products.
Mechanism & Function
Mechanism of Action
Combines the intracellular energy support expected from creatine with an inorganic-nitrate moiety that can raise plasma nitrate; the creatine portion may increase muscle creatine content while the nitrate may transiently increase circulating nitrate/nitrite.
Physiological Role
Provides a bioavailable creatine source for phosphocreatine resynthesis and a nitrate source that transiently increases plasma nitrate levels.
Primary Pathways
Performance / Health Relevance
May support short-term increases in maximal strength and lifting volume in some users and raise plasma nitrate transiently; effects on repeated-sprint, cycling time-trial or broad endurance outcomes are not consistently shown.
Evidence Review
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- 3 g/day (effects reported with 3 g and higher in trials)
- Optimal Range
- 3–6 g/day as used in human trials
- Upper / Caution Level
- Not established; trials administered up to 6 g/day for up to 6 days or 28 days without consistent safety signals
- Timing
- Once daily in trials; both acute single doses and daily supplementation over 5–28 days have been studied
- Best Format
- Oral powder/salt
- Bioavailability
- One trial reported increased plasma nitrate by day 7 with creatine nitrate, which then abated by day 28.
- Absorption Considerations
- Muscle creatine increased in some trials (similar to creatine monohydrate at equivalent creatine doses at early time points) but findings varied over 28 days.
Safety & Interactions
Side Effects
- •Minimal side effects reported in included trials; no consistent adverse events reported
Contraindications
- Not established in these trials
Drug Interactions
- •Not assessed in the provided abstracts
Who Should Avoid
- •Not established in these trials; clinical judgement advised for populations not studied
Monitoring
Human trials monitored blood chemistry and haemodynamics (blood pressure, heart rate) without consistent safety concerns over short durations.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Creatine Nitrate typically used or indicated?
Creatine Nitrate is most commonly used for: Increase strength/power, Short-term performance support, Pre-workout products, Cognitive alertness in combination products. Provides a bioavailable creatine source for phosphocreatine resynthesis and a nitrate source that transiently increases plasma nitrate levels.
How does Creatine Nitrate work?
Combines the intracellular energy support expected from creatine with an inorganic-nitrate moiety that can raise plasma nitrate; the creatine portion may increase muscle creatine content while the nitrate may transiently increase circulating nitrate/nitrite.
What is the recommended dose of Creatine Nitrate?
The optimal range is 3–6 g/day as used in human trials. with a minimum effective dose of 3 g/day (effects reported with 3 g and higher in trials). Best taken: Once daily in trials; both acute single doses and daily supplementation over 5–28 days have been studied. Upper / caution level: Not established; trials administered up to 6 g/day for up to 6 days or 28 days without consistent safety signals.
What are the side effects of Creatine Nitrate?
Reported side effects include: Minimal side effects reported in included trials; no consistent adverse events reported. Monitoring: Human trials monitored blood chemistry and haemodynamics (blood pressure, heart rate) without consistent safety concerns over short durations.
Does Creatine Nitrate interact with medications?
Known or theoretical interactions: Not assessed in the provided abstracts. Always check with a clinician before combining with prescription medication.
Who should avoid Creatine Nitrate?
Creatine Nitrate is generally not recommended for: Not established in these trials; clinical judgement advised for populations not studied; and Not established in these trials.
How strong is the evidence for Creatine Nitrate?
Evidence level: Moderate (overall score 57/100), based on 5 indexed studies on SuppIndex.
Research & References (5)
The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial.
Randomized, double-blind, crossover trial in 12 resistance-trained men comparing 7 days of creatine nitrate (5 g/day), caffeine (400 mg/day), their combination, and placebo. Assessed resistance exercise, Wingate, cognition and cardiovascular responses.
Hematological and Hemodynamic Responses to Acute and Short-Term Creatine Nitrate Supplementation.
Double-blind randomized crossover trial in 28 men and women comparing placebo, 3 g/day creatine nitrate and 6 g/day creatine nitrate for 6 days with washout. Measured hemodynamics, blood markers, and performance (1RM bench, leg press, cycling time trial).
Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance.
Two-part randomized trial: acute tolerability (N=13) to single doses and a 28-day randomized double-blind trial (N=48) with 1.5 g, 3 g creatine nitrate, 5 g creatine monohydrate and placebo; measured safety labs, bench press performance, Wingate and sprint tests.
Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males.
Randomized, double-blind trial in 80 resistance-trained males ingesting a multi-ingredient pre-workout supplement containing 2 g creatine nitrate (or the same with synephrine) or placebo for 8 weeks during training; measured body composition, strength, anaerobic capacity and cognition.
Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance.
Randomized, double-blind, counterbalanced acute trial in 25 recreationally active men and women ingesting a multi-ingredient pre-workout containing 2 g creatine nitrate (or plus synephrine) or placebo; measured resting energy expenditure, cognition, exercise performance and safety markers.
Related Ingredients
Other top-rated ingredients in Ergogenic Compounds.
Creatine Monohydrate
94/100A naturally occurring nitrogenous organic acid that facilitates recycling of adenosine triphosphate (ATP) in muscle and brain tissue via the phosphocreatine shuttle.
Maltodextrin
78/100Short-chain α-1,4 linked glucose polymer that is rapidly hydrolysed by brush-border maltase to glucose; near-equivalent glycaemic response to glucose but lower osmolality at concentration.
Cyclic Dextrin (HBCD)
72/100Produced via cyclic-glucanotransferase action on amylopectin, HBCD forms cluster-like macromolecules ~160 kDa that solubilise at low osmolality (≈4 mOsm/L) and clear the stomach faster than maltodextrin or glucose polymers.
Research Overview
Moderate EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/creatine-nitrate
SuppIndex. (2026). Creatine Nitrate: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/creatine-nitrate
Based on 5 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
Often included in multi-ingredient pre-workout formulations; when co-ingested with caffeine some cognitive benefits were reported, but studies cannot isolate creatine nitrate's unique contribution in multi-ingredient products.