Research Library

ClinicalTrials.gov NCT07595575 (Traylor, Nutraceutical Innovations LLC; collaborators: University of Toronto, Queen's, Arkansas, DePaul). Registered acute-feeding RCT investigating LEUVATE on post-ingestion glycemia, insulinemia, aminoacidemia and whole-body protein synthesis in adults prescribed GLP-1 receptor agonists. Not yet recruiting at time of listing — the first product-specific human trial on the LEUVATE brand.

Placebo-controlled randomized trial (n=299) of 2 g/day carnosine over ~12 weeks assessing multiple physical performance measures.

Double-blind RCT in 29 club-level rugby players compared 38 g/day bovine colostrum versus soy protein for 8 weeks. Assessed strength, power, aerobic fitness, body composition and salivary immune/inflammatory markers.

Randomised double‑blind 8‑week trial in 36 perimenopausal and menopausal women comparing low and medium doses of creatine hydrochloride, a creatine hydrochloride plus creatine ethyl ester group, and placebo. Medium‑dose creatine hydrochloride improved reaction time, increased frontal brain creatine, and improved lipid profile versus placebo. The creatine hydrochloride plus creatine ethyl ester group (800 mg/day listed) was included but specific effects attributable to CEE alone were not reported.

Randomised trial in 40 collegiate male soccer players during a 4‑week preparatory phase comparing creatine monohydrate, creatine ethyl ester, creatine hydrochloride and placebo alongside repeated sprint training. All training groups improved, but creatine supplement groups had greater changes than placebo; the CEE and HCl groups showed larger gains in physical performance and peak power than creatine monohydrate.

Randomised trial in 40 collegiate male soccer players over a 4‑week repeated sprint training period comparing creatine monohydrate, creatine ethyl ester, creatine hydrochloride and placebo. Assessed jumps, sprint times, Wingate power and incremental exercise tests.

Randomised, double‑blind trial in 36 perimenopausal and menopausal women over 8 weeks testing low (750 mg/day), medium (1500 mg/day) Cr‑HCl, Cr‑HCl plus creatine ethyl ester (800 mg/day), and placebo. Assessed cognition, brain creatine, clinical and biochemical markers.

Randomized double‑blind placebo‑controlled crossover pilot study in 20 IBS‑D patients testing a GABA‑based supplement versus placebo for two 4‑week periods separated by a 2‑week washout.

Randomised, placebo‑controlled trial in 842 peripubertal adolescents with HIV given weekly high‑dose vitamin D3 plus daily calcium carbonate 500 mg for 48 weeks. Primary bone density outcomes (TBLH‑BMD, LS‑BMAD) did not differ overall, but among those with vitamin D insufficiency at baseline a small improvement in lumbar spine BMAD Z score was observed.

2‑year ancillary study within COSMOS testing daily cocoa extract (500 mg cocoa flavanols/day including 80 mg (-)-epicatechin) versus placebo on five DNA methylation ageing clocks in 958 older adults.

Randomised crossover acute dietary study in healthy older adults consuming soups containing 0.5, 1 and 2 servings of oyster mushroom (rich in ergothioneine) and a calorie-matched control; outcomes assessed up to 6 hours post-consumption.

Systematic review framing ergothioneine as a candidate geroprotector, covering evidence from 2005–2025 and discussing pharmacokinetics via OCTN1 and potential to modulate hallmarks of ageing.

Randomised, double‑blind, placebo‑controlled 12‑week trial of green‑lipped mussel powder (1,000 mg/day) versus placebo in adults with symptomatic radiographic knee osteoarthritis. Primary endpoint was change in WOMAC total score.

Network meta-analysis including pharmacological and phytopharmaceutical treatments for anxiety disorders reported Silexan as both effective and as acceptable as placebo, and among few treatments with fewer adverse events than placebo.

Single-centre double-blind RCT of 120 patients with asymptomatic intracranial/carotid stenosis randomized to nattokinase 8,000 FU/day or placebo for 6 months, assessing cognition and brain MRI.

PRISMA-guided systematic review (2010–Oct 2025) of preclinical and clinical NAD+-related compound interventions, identifying 33 human intervention studies and 80 rodent studies.

Randomized, double-blind, crossover study in 14 male university rowers comparing four conditions (caffeine+paraxanthine, caffeine alone, paraxanthine alone, placebo), each with 200 mg doses, assessing 2000-m ergometer performance and subjective sleep measures.

Randomised, double-blind, placebo-controlled trial of a fungal mycelium product containing Fomitopsis officinalis and Trametes versicolor (FoTv) as an adjunct to COVID-19 vaccination; outcomes included safety, vaccine side-effects and anti‑SARS‑CoV‑2 antibody levels.

Meta-analysis of RCTs showing chamomile significantly reduces CRP and IL-6 in humans.

Traylor, Lees, Nunes, Phillips (Current Developments in Nutrition, 2025, 106209). The LEUCY leucine-enriched whey–casein blend produced higher early-postprandial plasma leucine and modestly elevated leucinemia across the 240-min post-feeding window vs comparator protein supplements — the first published human PK profile from the Leuvate research programme (DOI: 10.1016/j.cdnut.2025.106209).

Double‑blind RCT in elderly chronic kidney disease patients testing oral leucine‑enriched BCAA (60% leucine; 4.5 g leucine, total BCAA 7.5 g/day) versus placebo for 12 weeks.

Double-blind, randomised, placebo-controlled pilot trial in older adults (mean age ~71) assessing 500 mg/day yeast beta-glucan versus placebo given around seasonal influenza vaccination with antibody titres measured pre- and 4 weeks post-vaccination.

Randomized triple-blind placebo-controlled crossover pilot: ketone salt increased plasma acetoacetate and beta-hydroxybutyrate significantly compared with placebo in healthy adults 30 minutes after ingestion.

Systematic review of exogenous ketosis in adults with disease (51 studies): suggested potential benefits across neurological, metabolic and cardiovascular disorders but evidence often relied on surrogate endpoints and ketone esters were favoured for achieving tolerable therapeutic ketosis; results are preliminary.

Systematic review and network meta-analysis of dietary supplements in soccer players (80 RCTs). Bovine colostrum was one of several supplements associated with a moderate increase in distance covered relative to placebo in the network analysis.