Advifolate
A trademarked form of Vitamin B9 (L-Methylfolate / 5-MTHF)
Advifolate is a USP-grade L-5-MTHF calcium salt, the biologically active form of folate. No brand-specific clinical trials are indexed yet; evidence shown relates to the parent ingredient.
Manufacturer
VitaActives
Clinical Studies
0
Certifications
0
Purity
USP grade L-5-MTHF-Ca
Last reviewed: 2026-10-06
What Makes It Different
Active (methylated) folate form that does not require conversion by MTHFR.
Technical Specifications
Ingredient Type
L-5-methyltetrahydrofolate calcium salt
Purity / Standardisation
USP grade L-5-MTHF-Ca
Brand Owner
VitaActives
Country of Origin
United Kingdom
Frequently Asked Questions
What is Advifolate?
Advifolate is a trademarked form of Vitamin B9 (L-Methylfolate / 5-MTHF) manufactured by VitaActives. Advifolate is a USP-grade L-5-MTHF calcium salt, the biologically active form of folate. No brand-specific clinical trials are indexed yet; evidence shown relates to the parent ingredient.
How is Advifolate different from generic Vitamin B9 (L-Methylfolate / 5-MTHF)?
Active (methylated) folate form that does not require conversion by MTHFR.
Who makes Advifolate?
Advifolate is made by VitaActives (United Kingdom).
How much clinical evidence does Advifolate have?
SuppIndex lists 0 clinical studies for Advifolate. The parent ingredient Vitamin B9 (L-Methylfolate / 5-MTHF) has an overall evidence score of 75/100 (Strong).
Parent Ingredient
Vitamin B9 (L-Methylfolate / 5-MTHF)
L-Methylfolate is the principal circulating form of folate and the only form that can cross the blood-brain barrier. It plays a critical role as a coenzyme in one-carbon metabolism, particularly in the methylation cycle. Its direct bioavailability makes it a preferred supplemental form, especially when addressing folate deficiencies or supporting processes requiring efficient methylation, such as neurotransmitter synthesis and homocysteine regulation. Research indicates its efficacy in supporting mood, cardiovascular health, and cognitive function, particularly in populations with impaired folate metabolism.
View the parent ingredient page for full evidence review, dosage guidance, mechanism of action, and safety information.
Manufacturer
VitaActives
United Kingdom
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