Serratiopeptidase
Also known as: Serrapeptase, Serratia peptidase
As a protein, serratiopeptidase is largely digested in the gut; enteric coating may allow some absorption, but demonstrated systemic proteolytic activity after oral dosing in humans is weak. Most supportive studies are small, older or industry-linked.
Last reviewed: 2026-10-06 · 0 indexed studies
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Overview
Serratiopeptidase (serrapeptase) is a proteolytic enzyme originally isolated from silkworm-gut bacteria. It is marketed as a 'systemic enzyme' for inflammation and recovery, but the human evidence base is thin and oral absorption of an intact enzyme is physiologically uncertain.
Mechanism & Function
Mechanism of Action
In vitro, it hydrolyses fibrin, bradykinin and inflammatory mediators. Whether meaningful enzyme activity reaches the bloodstream after oral dosing remains unproven.
Physiological Role
No physiological role; an exogenous bacterial protease.
Primary Pathways
Performance / Health Relevance
Marketed for recovery; no credible performance evidence.
Evidence Review
No human clinical studies indexed for this ingredient yet.
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- Not established
- Optimal Range
- Products typically provide 10–60 mg (20,000–120,000 SPU) daily — efficacy unproven
- Upper / Caution Level
- Not well defined
- Timing
- On an empty stomach (to favour absorption rather than protein digestion)
- Best Format
- Enteric-coated, activity-standardised (SPU) preparations
- Bioavailability
- Oral bioavailability of the intact enzyme is uncertain — the central open question for this ingredient.
- Absorption Considerations
- Enteric coating is used to protect the enzyme from gastric digestion.
Safety & Interactions
Side Effects
- •GI upset
- •Rare allergic reactions
Contraindications
- Bleeding disorders (theoretical)
- Upcoming surgery (theoretical bleeding risk)
Drug Interactions
- •Anticoagulants (theoretical additive bleeding risk)
Who Should Avoid
- •People on blood thinners (caution)
- •Before surgery
Monitoring
Stop before planned surgery.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Serratiopeptidase typically used or indicated?
Serratiopeptidase is most commonly used for: Systemic-enzyme supplements, Recovery and inflammation-balance formulas. No physiological role; an exogenous bacterial protease.
How does Serratiopeptidase work?
In vitro, it hydrolyses fibrin, bradykinin and inflammatory mediators. Whether meaningful enzyme activity reaches the bloodstream after oral dosing remains unproven.
What is the recommended dose of Serratiopeptidase?
The optimal range is Products typically provide 10–60 mg (20,000–120,000 SPU) daily — efficacy unproven. with a minimum effective dose of Not established. Best taken: On an empty stomach (to favour absorption rather than protein digestion). Upper / caution level: Not well defined.
What are the side effects of Serratiopeptidase?
Reported side effects include: GI upset; and Rare allergic reactions. Monitoring: Stop before planned surgery.
Does Serratiopeptidase interact with medications?
Known or theoretical interactions: Anticoagulants (theoretical additive bleeding risk). Always check with a clinician before combining with prescription medication.
Who should avoid Serratiopeptidase?
Serratiopeptidase is generally not recommended for: People on blood thinners (caution); Before surgery; Bleeding disorders (theoretical); and Upcoming surgery (theoretical bleeding risk).
How strong is the evidence for Serratiopeptidase?
Evidence level: Preliminary (overall score 20/100), based on 0 indexed studies on SuppIndex.
Research & References (0)
No studies match this filter
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Research Overview
Preliminary EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/serratiopeptidase
SuppIndex. (2026). Serratiopeptidase: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/serratiopeptidase
Based on 0 indexed studies · Evidence level: Preliminary.
Goal Ratings
Stack Compatibility
Sometimes combined with bromelain or nattokinase in systemic-enzyme products.