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    Evidence Comparison

    Compare Ingredients

    Compare the research strength, evidence scores, goal ratings, and safety profiles of up to 4 ingredients side by side.

    Data last reviewed: 2026-06-28

    Whey Protein Isolate (WPI)Hydrolysed Whey Protein (WPH)

    Who wins on evidence?

    Whey Protein Isolate (WPI) winsby 9 pts (94% vs 85%)

    Averaged across overall, human clinical, meta-analysis, mechanistic, real-world and safety scores.

    Whey Protein Isolate (WPI)94%
    Overall: 94/100Human Clinical: 96/100Meta-Analysis: 96/100Mechanistic: 95/100Real-World: 92/100Safety: 92/100
    Hydrolysed Whey Protein (WPH)85%
    Overall: 84/100Human Clinical: 86/100Meta-Analysis: 80/100Mechanistic: 92/100Real-World: 80/100Safety: 90/100

    Verdict is calculated from objective evidence signals only (clinical research volume, evidence quality, validation markers). It does not account for individual goals or tolerability.

    Evidence Scores

    Overall
    Whey Protein Isolate (WPI)
    94★
    Hydrolysed Whey Protein (WPH)
    84
    Human Clinical
    Whey Protein Isolate (WPI)
    96★
    Hydrolysed Whey Protein (WPH)
    86
    Meta-Analysis
    Whey Protein Isolate (WPI)
    No meta-analyses or systematic reviews indexed for this ingredient yet.
    N/A
    Hydrolysed Whey Protein (WPH)
    No meta-analyses or systematic reviews indexed for this ingredient yet.
    N/A
    Mechanistic
    Whey Protein Isolate (WPI)
    95★
    Hydrolysed Whey Protein (WPH)
    92
    Real-World
    Whey Protein Isolate (WPI)
    92★
    Hydrolysed Whey Protein (WPH)
    80
    Safety
    Whey Protein Isolate (WPI)
    92★
    Hydrolysed Whey Protein (WPH)
    90

    Research Volume

    Metric
    Whey Protein Isolate (WPI)
    Hydrolysed Whey Protein (WPH)
    Evidence Level94/10084/100
    Total Studies22
    Human Trials22
    Meta-Analyses00
    Latest Study20142010
    Athlete Studies21
    CategoryProteins & Protein PowdersProteins & Protein Powders
    OriginNaturalNatural
    Trademarks——

    Goal Ratings

    Muscle Gain
    Whey Protein Isolate (WPI)
    5
    Hydrolysed Whey Protein (WPH)
    5
    Recovery
    Whey Protein Isolate (WPI)
    5
    Hydrolysed Whey Protein (WPH)
    5
    Strength
    Whey Protein Isolate (WPI)
    4
    Hydrolysed Whey Protein (WPH)
    4
    Fat Loss
    Whey Protein Isolate (WPI)
    4
    Hydrolysed Whey Protein (WPH)
    —
    General Health
    Whey Protein Isolate (WPI)
    4
    Hydrolysed Whey Protein (WPH)
    —

    Safety Overview

    Aspect
    Whey Protein Isolate (WPI)
    Hydrolysed Whey Protein (WPH)
    Safety Score92/10090/100
    Side EffectsRare GI discomfort; Acne in predisposed individuals (anecdotal)Bitter taste; Rare GI discomfort
    ContraindicationsMilk protein allergySevere cow's milk allergy (extensively hydrolysed forms may still trigger reactions)
    Drug Interactions1 known1 known
    Effective Dosage20–40 g per serving, 1.6–2.2 g/kg/day total protein20–30 g per serving

    Quick Verdict

    Whey Protein Isolate (WPI)
    94/100

    2 studies

    Muscle GainRecoveryStrength
    Hydrolysed Whey Protein (WPH)
    84/100

    2 studies

    Muscle GainRecoveryStrength

    Citations

    Whey Protein Isolate (WPI)(2 studies)

    1. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise (2014, RCT) https://pubmed.ncbi.nlm.nih.gov/24257722/
    2. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men (2009, RCT) https://pubmed.ncbi.nlm.nih.gov/19589961/

    Hydrolysed Whey Protein (WPH)(2 studies)

    1. Supplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exercise (2010, RCT) https://pubmed.ncbi.nlm.nih.gov/19945843/
    2. Whey protein hydrolysate enhances the postprandial muscular protein synthesis response in healthy elderly men (2009, RCT) https://pubmed.ncbi.nlm.nih.gov/19625698/