Bacillus coagulans GBI-30 6086
Also known as: GanedenBC30®, B. coagulans 6086, Spore-forming probiotic
Bacillus coagulans GBI-30 6086 produces L(+) lactic acid (the bioactive isomer), germinates from spore to vegetative cell in the small intestine, and is cleared within 7 days. Studied in over 25 clinical trials including unique sports-nutrition applications.
Last reviewed: 2025-01-15 · 3 indexed studies
Set your location for accurate regulatory status
Saved on this device — no sign-in needed.
Overview
A spore-forming probiotic that survives ambient storage, gastric acid, and food-processing heat — making it uniquely suited to fortified foods, shakes, and shelf-stable products. Strongest probiotic evidence for sports recovery and protein absorption.
Mechanism & Function
Mechanism of Action
Spores germinate in the duodenum; vegetative cells produce L(+) lactate, lower luminal pH, and out-compete pathogens. Stimulate CD3/CD8 T-cell response to adenovirus and influenza A. Improve protein digestion via co-secreted proteases.
Physiological Role
Enhances protein utilisation when co-ingested with casein/pea protein; reduces exercise-induced muscle damage markers; modulates immune defence.
Primary Pathways
Performance / Health Relevance
Co-ingestion with protein has been shown to increase post-exercise recovery markers and reduce CK rise after damaging exercise (Jäger 2016, 2019).
Evidence Review
No meta-analyses or systematic reviews indexed for this ingredient yet.
Dimensions marked N/A have no indexed evidence of that class. They are shown as unavailable rather than scored.
Practical Use & Dosage
- Minimum Effective Dose
- 500 million CFU/day
- Optimal Range
- 1–3 billion CFU/day
- Upper / Caution Level
- Up to 10 billion CFU well tolerated
- Timing
- Daily; co-ingest with protein for athletic benefit
- Best Format
- Spore-form capsule, tablet, or fortified food/drink (heat-stable)
- Bioavailability
- Spore form survives 100°C processing and gastric acid intact.
- Absorption Considerations
- Germinates in duodenum; transient — daily intake required.
Safety & Interactions
Side Effects
- •Mild flatulence (rare)
Contraindications
- Severe immunocompromise
Drug Interactions
- •None clinically significant
Who Should Avoid
- •ICU patients with central lines
Monitoring
None.
Frequently Asked Questions
Auto-generated from indexed evidence — dosage, safety, interactions, and more.
When is Bacillus coagulans GBI-30 6086 typically used or indicated?
Bacillus coagulans GBI-30 6086 is most commonly used for: IBS, Post-exercise recovery, Protein utilisation, Immune support. Enhances protein utilisation when co-ingested with casein/pea protein; reduces exercise-induced muscle damage markers; modulates immune defence.
How does Bacillus coagulans GBI-30 6086 work?
Spores germinate in the duodenum; vegetative cells produce L(+) lactate, lower luminal pH, and out-compete pathogens. Stimulate CD3/CD8 T-cell response to adenovirus and influenza A. Improve protein digestion via co-secreted proteases.
What is the recommended dose of Bacillus coagulans GBI-30 6086?
The optimal range is 1–3 billion CFU/day. with a minimum effective dose of 500 million CFU/day. Best taken: Daily; co-ingest with protein for athletic benefit. Upper / caution level: Up to 10 billion CFU well tolerated.
What are the side effects of Bacillus coagulans GBI-30 6086?
Reported side effects include: Mild flatulence (rare). Monitoring: None.
Does Bacillus coagulans GBI-30 6086 interact with medications?
Known or theoretical interactions: None clinically significant. Always check with a clinician before combining with prescription medication.
Who should avoid Bacillus coagulans GBI-30 6086?
Bacillus coagulans GBI-30 6086 is generally not recommended for: ICU patients with central lines; and Severe immunocompromise.
How strong is the evidence for Bacillus coagulans GBI-30 6086?
Evidence level: Moderate (overall score 74/100), based on 3 indexed studies on SuppIndex.
Research & References (3)
Probiotic Bacillus coagulans GBI-30, 6086 improves protein absorption and utilization
Jäger R et al. Crossover RCT — co-ingestion with milk protein increased post-meal amino acid availability (leucine AUC +6%).
Probiotic administration attenuates muscle damage and improves recovery after damaging exercise
Jäger R et al. 2-week supplementation reduced CK rise, soreness, and improved recovery of vertical jump after eccentric exercise.
Bacillus coagulans GBI-30, 6086 reduces exercise-induced muscle damage and increases recovery in healthy adults
Majeed M et al. 12-week supplementation in IBS patients reduced abdominal pain and bloating vs placebo.
Related Ingredients
Other top-rated ingredients in Digestive Enzymes, Probiotics & Fibers.
Psyllium Husk
88/100Psyllium is composed of highly branched arabinoxylan that hydrates into a viscous gel in the small intestine. Unlike most viscous fibres it is only partially fermented in the colon, retaining water-holding capacity throughout the GI tract.
Saccharomyces boulardii CNCM I-745
85/100Saccharomyces cerevisiae var. boulardii strain CNCM I-745 is a transient yeast that survives gastric transit, reaches steady-state colonic concentrations within 3 days, and is cleared 3–5 days after stopping. It works via secreted proteases, anti-inflammatory signalling, and pathogen binding rather than colonisation.
Lactobacillus Rhamnosus GG
80/100A Gram-positive facultative anaerobic bacterium that adheres to intestinal mucosa, modulates innate/adaptive immune responses, and strengthens tight junction protein expression.
Research Overview
Moderate EvidenceCite this ingredient
One-click citation export in APA, MLA, Chicago, BibTeX, or HTML. The URL below is stable and safe to link.
Stable URL
https://thesuppindex.com/ingredients/bacillus-coagulans-gbi-30
SuppIndex. (2026). Bacillus coagulans GBI-30 6086: Evidence summary, dosage and clinical studies. Retrieved October 16, 2026, from https://thesuppindex.com/ingredients/bacillus-coagulans-gbi-30
Based on 3 indexed studies · Evidence level: Moderate.
Goal Ratings
Stack Compatibility
Pairs well with whey/pea protein and digestive enzymes.